Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

Ivano Riva, Lorenzo Legramandi, Eliana Rulli, Anastasios G Konstas, Andreas Katsanos, Francesco Oddone, Robert N Weinreb, Luciano Quaranta, Italian Study Group on QoL in Glaucoma

Research output: Contribution to journalArticle


To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p 
Original languageEnglish
Pages (from-to)6735
Number of pages1
JournalSci. Rep.
Issue number1
Publication statusPublished - May 1 2019


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