Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis

E. Castaldi, G. M. Cicchini, L. Cinelli, Laura Biagi, S. Rizzo, M. C. Morrone

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Retinal prosthesis technologies require that the visual system downstream of the retinal circuitry be capable of transmitting and elaborating visual signals. We studied the capability of plastic remodeling in late blind subjects implanted with the Argus II Retinal Prosthesis with psychophysics and functional MRI (fMRI). After surgery, six out of seven retinitis pigmentosa (RP) blind subjects were able to detect high-contrast stimuli using the prosthetic implant. However, direction discrimination to contrast modulated stimuli remained at chance level in all of them. No subject showed any improvement of contrast sensitivity in either eye when not using the Argus II. Before the implant, the Blood Oxygenation Level Dependent (BOLD) activity in V1 and the lateral geniculate nucleus (LGN) was very weak or absent. Surprisingly, after prolonged use of Argus II, BOLD responses to visual input were enhanced. This is, to our knowledge, the first study tracking the neural changes of visual areas in patients after retinal implant, revealing a capacity to respond to restored visual input even after years of deprivation.

Original languageEnglish
Article numbere1002569
JournalPLoS Biology
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 25 2016

Fingerprint

Visual Prosthesis
prostheses
Oxygenation
Blood
Psychophysics
Geniculate Bodies
Contrast Sensitivity
Retinitis Pigmentosa
blood
Surgery
Plastics
Magnetic Resonance Imaging
Technology
plastics
surgery
eyes
Prostheses and Implants

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. / Castaldi, E.; Cicchini, G. M.; Cinelli, L.; Biagi, Laura; Rizzo, S.; Morrone, M. C.

In: PLoS Biology, Vol. 14, No. 10, e1002569, 25.10.2016.

Research output: Contribution to journalArticle

Castaldi, E. ; Cicchini, G. M. ; Cinelli, L. ; Biagi, Laura ; Rizzo, S. ; Morrone, M. C. / Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. In: PLoS Biology. 2016 ; Vol. 14, No. 10.
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