Visual cortex hyperexcitability in idiopathic generalized epilepsies with photosensitivity: A TMS pilot study

Francesco Brigo, Luigi Giuseppe Bongiovanni, Raffaele Nardone, Eugen Trinka, Frediano Tezzon, Antonio Fiaschi, Paolo Manganotti

Research output: Contribution to journalArticle

Abstract

Background: The current understanding of the mechanisms underlying photosensitivity is still limited, although most studies point to a hyperexcitability of the visual cortex. Methods: Using transcranial magnetic stimulation, we determined the resting motor threshold (rMT) and the phosphene threshold (PT) in 33 patients with IGEs (8 with photosensitivity) compared with 12 healthy controls. Results: Eleven controls (92%) reported phosphenes compared with fifteen (46%) patients with idiopathic generalized epilepsy (p =0.015). Phosphenes were reported more frequently among patients with epilepsy with photosensitivity (87.5%) than in patients with active epilepsy without photosensitivity (30.8%) (p =0.038) and patients with epilepsy in remission without photosensitivity (33.3%) (p =0.054); no differences were found between patients with epilepsy with photosensitivity and controls (p =0.648). Resting motor threshold and phosphene threshold were significantly higher among patients with epilepsy (active epilepsy or epilepsy in remission without photosensitivity) compared to healthy controls (p

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalEpilepsy and Behavior
Volume27
Issue number2
DOIs
Publication statusPublished - May 2013

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Visual Cortex
Phosphenes
Epilepsy
Transcranial Magnetic Stimulation
Idiopathic Generalized Epilepsy

Keywords

  • Idiopathic generalized epilepsy
  • Motor threshold
  • Phosphene threshold
  • Photosensitivity
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Brigo, F., Bongiovanni, L. G., Nardone, R., Trinka, E., Tezzon, F., Fiaschi, A., & Manganotti, P. (2013). Visual cortex hyperexcitability in idiopathic generalized epilepsies with photosensitivity: A TMS pilot study. Epilepsy and Behavior, 27(2), 301-306. https://doi.org/10.1016/j.yebeh.2013.02.010

Visual cortex hyperexcitability in idiopathic generalized epilepsies with photosensitivity : A TMS pilot study. / Brigo, Francesco; Bongiovanni, Luigi Giuseppe; Nardone, Raffaele; Trinka, Eugen; Tezzon, Frediano; Fiaschi, Antonio; Manganotti, Paolo.

In: Epilepsy and Behavior, Vol. 27, No. 2, 05.2013, p. 301-306.

Research output: Contribution to journalArticle

Brigo, F, Bongiovanni, LG, Nardone, R, Trinka, E, Tezzon, F, Fiaschi, A & Manganotti, P 2013, 'Visual cortex hyperexcitability in idiopathic generalized epilepsies with photosensitivity: A TMS pilot study', Epilepsy and Behavior, vol. 27, no. 2, pp. 301-306. https://doi.org/10.1016/j.yebeh.2013.02.010
Brigo, Francesco ; Bongiovanni, Luigi Giuseppe ; Nardone, Raffaele ; Trinka, Eugen ; Tezzon, Frediano ; Fiaschi, Antonio ; Manganotti, Paolo. / Visual cortex hyperexcitability in idiopathic generalized epilepsies with photosensitivity : A TMS pilot study. In: Epilepsy and Behavior. 2013 ; Vol. 27, No. 2. pp. 301-306.
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