Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions

Filippo Brighina, Nadia Bolognini, Giuseppe Cosentino, Simona MacCora, Piera Paladino, Roberta Baschi, Giuseppe Vallar, Brigida Fierro

Research output: Contribution to journalArticle

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Abstract

Sound-induced flash illusions depend on visual cortical excitability. In this study, we explored whether sound-induced flash illusions are perceived differently in migraine, a condition associated with pathologic cortical hyperexcitability. Methods: Sound-induced flash illusions were examined in 59 migraine patients (mean age 32 ± 16 years; 36 females), 32 without aura and 27 with aura, and in 24 healthy controls (mean age 42 ± 17 years; 16 females). Patients were studied during attacks and interictally. Visual stimuli (flashes) accompanied by sounds (beeps) were presented in different combinations: a single flash with multiple beeps was given to induce the perception of multiple flashes ("fission" illusion), and multiple flashes with a single beep were used to reduce the number of perceived flashes ("fusion" illusion). Results: For migraineurs, the fission illusion was reduced, especially during the attack, and almost abolished when a single flash was combined with 2 beeps (except for those without aura tested interictally); the fusion illusion was less consistently reported in both migraine groups, but not completely disrupted. Conclusions: Results from this study add novel clues to our understanding of visual cortex hyperexcitability in migraine, especially migraine with aura. Furthermore, these analyses underscore how pathologic changes in cortical excitability affect multisensory interactions. Cross-modal illusions represent a valid tool for exploration of functional connectivity between sensory areas, which likely has an important role in the pathophysiology of migraine.

Original languageEnglish
Pages (from-to)2057-2061
Number of pages5
JournalNeurology
Volume84
Issue number20
DOIs
Publication statusPublished - May 19 2015

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Visual Cortex
Migraine Disorders
Epilepsy
Migraine with Aura

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

Cite this

Brighina, F., Bolognini, N., Cosentino, G., MacCora, S., Paladino, P., Baschi, R., ... Fierro, B. (2015). Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions. Neurology, 84(20), 2057-2061. https://doi.org/10.1212/WNL.0000000000001584

Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions. / Brighina, Filippo; Bolognini, Nadia; Cosentino, Giuseppe; MacCora, Simona; Paladino, Piera; Baschi, Roberta; Vallar, Giuseppe; Fierro, Brigida.

In: Neurology, Vol. 84, No. 20, 19.05.2015, p. 2057-2061.

Research output: Contribution to journalArticle

Brighina, F, Bolognini, N, Cosentino, G, MacCora, S, Paladino, P, Baschi, R, Vallar, G & Fierro, B 2015, 'Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions', Neurology, vol. 84, no. 20, pp. 2057-2061. https://doi.org/10.1212/WNL.0000000000001584
Brighina, Filippo ; Bolognini, Nadia ; Cosentino, Giuseppe ; MacCora, Simona ; Paladino, Piera ; Baschi, Roberta ; Vallar, Giuseppe ; Fierro, Brigida. / Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions. In: Neurology. 2015 ; Vol. 84, No. 20. pp. 2057-2061.
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