Visual evaluation of binding to mucosal cells of a medical device against the common cold

Pier Carlo Braga, Marina Alfieri, Monica Dal Sasso, Maria Culici

Research output: Contribution to journalArticle

Abstract

The objective of this study was to investigate the possibility of visualizing the ability of hydroxypropylmethylcellulose (HPMC) and a nasal spray (First Defense), in which the bioadhesive is HPMC, to bind to human mucosal cells using inorganic (black carbon particles and Congo red dye) and organic markers (Escherichia coli). A significant reduction in the bacterial adhesiveness has been observed. Our findings indicate the possibility of counteracting the lock-and-key mechanism of microorganism adhesion using the bioadhesive properties of polymers, such as HPMC, in First Defense to prevent a possible contact between adhesins and complementary receptors.

Original languageEnglish
Pages (from-to)459-464
Number of pages6
JournalDrug Development and Industrial Pharmacy
Volume34
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • Bioadhesives
  • Carbon black
  • Congo red
  • Escherichia coli
  • First defense
  • Hydroxypropylmethylcellulose

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Fingerprint Dive into the research topics of 'Visual evaluation of binding to mucosal cells of a medical device against the common cold'. Together they form a unique fingerprint.

  • Cite this