Visual Evoked Potentials as a Biomarker in Multiple Sclerosis and Associated Optic Neuritis

L Leocani, Simone Guerrieri, G Comi

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is an inflammatory, degenerative disease of the central nervous system (CNS) characterized by progressive neurological decline over time. The need for better "biomarkers" to more precisely capture and track the effects of demyelination, remyelination, and associated neuroaxonal injury is a well-recognized challenge in the field of MS. To this end, visual evoked potentials (VEPs) have a role in assessing the extent of demyelination along the optic nerve, as a functionally eloquent CNS region. Moreover, VEPs testing can be used to predict the extent of recovery after optic neuritis (ON) and capture disabling effects of clinical and subclinical demyelination events in the afferent visual pathway. In this review, the evolving role of VEPs in the diagnosis of patients with ON and MS and the utility of VEPs testing in determining therapeutic benefits of emerging MS treatments is discussed. © 2018 by North American Neuro-Ophthalmology Society.
Original languageEnglish
Pages (from-to)350-357
Number of pages8
JournalJournal of Neuro-Ophthalmology
Volume38
Issue number3
DOIs
Publication statusPublished - 2018

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