Visual evoked potentials generator model derived from different spatial frequency stimuli of visual Field regions and magnetic resonance imaging coordinates of v1, v2, v3 areas in man

Marco Onofrj, Tommaso Fulgente, Astrid Thomas, Luigi Curatola, Marco Peresson, Luisa Lopez, Tiziana Locatelli, Vittorio Martinelli, Giancarlo Comi

Research output: Contribution to journalArticle

Abstract

Visual evoked potentials (VEPs) to pattern reversal vertical bar stimuli were recorded from 24 scalp derivations (including zygomatic and inion) referenced to digitally linked earlobes in 50 controls. 1,2 and 4 cpd patterns were presented as full field (FF) stimuli, on Upper Hemifields (UHF) and Lower Hemifields (LHF), upper and lower quadrants and with the occlusion of central and peripheral UHF and LHF. VEPs to octant stimuli were also recorded with 2 cpd patterns. N1, P1 and N2 components were recorded from posterior and inion derivations with FF stimuli, from posterior derivations with LHF stimuli, only from inion leads with UHF stimuli, from derivations ipsilateral to stimuli with quadrants and octants, and consistently from midline derivations only with lower quadrants. Polarity inverted sequences (iN1-iP1-iN2) were recorded from the other scalp derivations, with similar latency and spatial frequency sensitivity as N1-P1-N2. Single Equivalent Dipole (ED) calculations were performed on NI and PI recorded in the different stimulus conditions. Our findings contradict previous hypotheses on VEP generators and contradict the predictions of VEPs polarity and distribution based on the cruciform model" of VEPs generators. In order to explain the distribution of VEPs to upper and lower half fields and to quadrant and octants, we propose a model based on the position of the medial and occipito-polar surface of visual cortex in man.

Original languageEnglish
Pages (from-to)213-239
Number of pages27
JournalInternational Journal of Neuroscience
Volume83
Issue number3-4
DOIs
Publication statusPublished - 1995

Keywords

  • Topographic mapping
  • Visual cortex
  • Visual evoked responses
  • Visual pathways

ASJC Scopus subject areas

  • Neuroscience(all)

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