Abstract
Background: Patients suffering from migraine with aura can have either pure visual auras or complex auras with sensory disturbances and dysphasia, or both. Few studies have searched for possible pathophysiological differences between these two subgroups of patients. Methods: Methods - Forty-seven migraine with aura patients were subdivided in a subgroup with exclusively visual auras (MA, N = 27) and another with complex neurological auras (MA+, N = 20). We recorded pattern-reversal visual evoked potentials (VEP: 15 min of arc cheques, 3.1 reversal per second, 600 sweeps) and measured amplitude and habituation (slope of the linear regression line of amplitude changes from the 1st to 6th block of 100 sweeps) for the N1-P1 and P1-N2 components in patients and, for comparison, in 30 healthy volunteers (HV) of similar age and gender distribution. Results: VEP N1-P1 habituation, i.e. amplitude decrement between 1st and 6th block, which was obvious in most HV (mean slope −0.50), was deficient in both MA (slope +0.01, p = 0.0001) and MA+ (−0.0049, p = 0.001) patients. However, VEP N1-P1 amplitudes across blocks were normal in MA patients, while they were significantly greater in MA+ patients than in HVs. Conclusions: Our findings suggest that in migraine with aura patients different aura phenotypes may be underpinned by different pathophysiological mechanisms. Pre-activation cortical excitability could be higher in patients with complex neurological auras than in those having pure visual auras or in healthy volunteers.
| Original language | English |
|---|---|
| Article number | 92 |
| Journal | Journal of Headache and Pain |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 1 2015 |
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Keywords
- Complex aura
- Cortical excitability
- Habituation
- Migraine with aura
- Visual aura
- Visual evoked potentials
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
- Clinical Neurology
Cite this
Visual evoked potentials in subgroups of migraine with aura patients. / Coppola, Gianluca; Bracaglia, Martina; Di Lenola, Davide; Di Lorenzo, Cherubino; Serrao, Mariano; Parisi, Vincenzo; Di Renzo, Antonio; Martelli, Francesco; Fadda, Antonello; Schoenen, Jean; Pierelli, Francesco.
In: Journal of Headache and Pain, Vol. 16, No. 1, 92, 01.12.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Visual evoked potentials in subgroups of migraine with aura patients
AU - Coppola, Gianluca
AU - Bracaglia, Martina
AU - Di Lenola, Davide
AU - Di Lorenzo, Cherubino
AU - Serrao, Mariano
AU - Parisi, Vincenzo
AU - Di Renzo, Antonio
AU - Martelli, Francesco
AU - Fadda, Antonello
AU - Schoenen, Jean
AU - Pierelli, Francesco
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background: Patients suffering from migraine with aura can have either pure visual auras or complex auras with sensory disturbances and dysphasia, or both. Few studies have searched for possible pathophysiological differences between these two subgroups of patients. Methods: Methods - Forty-seven migraine with aura patients were subdivided in a subgroup with exclusively visual auras (MA, N = 27) and another with complex neurological auras (MA+, N = 20). We recorded pattern-reversal visual evoked potentials (VEP: 15 min of arc cheques, 3.1 reversal per second, 600 sweeps) and measured amplitude and habituation (slope of the linear regression line of amplitude changes from the 1st to 6th block of 100 sweeps) for the N1-P1 and P1-N2 components in patients and, for comparison, in 30 healthy volunteers (HV) of similar age and gender distribution. Results: VEP N1-P1 habituation, i.e. amplitude decrement between 1st and 6th block, which was obvious in most HV (mean slope −0.50), was deficient in both MA (slope +0.01, p = 0.0001) and MA+ (−0.0049, p = 0.001) patients. However, VEP N1-P1 amplitudes across blocks were normal in MA patients, while they were significantly greater in MA+ patients than in HVs. Conclusions: Our findings suggest that in migraine with aura patients different aura phenotypes may be underpinned by different pathophysiological mechanisms. Pre-activation cortical excitability could be higher in patients with complex neurological auras than in those having pure visual auras or in healthy volunteers.
AB - Background: Patients suffering from migraine with aura can have either pure visual auras or complex auras with sensory disturbances and dysphasia, or both. Few studies have searched for possible pathophysiological differences between these two subgroups of patients. Methods: Methods - Forty-seven migraine with aura patients were subdivided in a subgroup with exclusively visual auras (MA, N = 27) and another with complex neurological auras (MA+, N = 20). We recorded pattern-reversal visual evoked potentials (VEP: 15 min of arc cheques, 3.1 reversal per second, 600 sweeps) and measured amplitude and habituation (slope of the linear regression line of amplitude changes from the 1st to 6th block of 100 sweeps) for the N1-P1 and P1-N2 components in patients and, for comparison, in 30 healthy volunteers (HV) of similar age and gender distribution. Results: VEP N1-P1 habituation, i.e. amplitude decrement between 1st and 6th block, which was obvious in most HV (mean slope −0.50), was deficient in both MA (slope +0.01, p = 0.0001) and MA+ (−0.0049, p = 0.001) patients. However, VEP N1-P1 amplitudes across blocks were normal in MA patients, while they were significantly greater in MA+ patients than in HVs. Conclusions: Our findings suggest that in migraine with aura patients different aura phenotypes may be underpinned by different pathophysiological mechanisms. Pre-activation cortical excitability could be higher in patients with complex neurological auras than in those having pure visual auras or in healthy volunteers.
KW - Complex aura
KW - Cortical excitability
KW - Habituation
KW - Migraine with aura
KW - Visual aura
KW - Visual evoked potentials
UR - http://www.scopus.com/inward/record.url?scp=84946060556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946060556&partnerID=8YFLogxK
U2 - 10.1186/s10194-015-0577-6
DO - 10.1186/s10194-015-0577-6
M3 - Article
AN - SCOPUS:84946060556
VL - 16
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
SN - 1129-2369
IS - 1
M1 - 92
ER -