Abstract
Vigabatrin is considered the drug of choice for infantile spasms and simple and complex partial epilepsy in childhood. Its mechanism of action relies on the irreversible inhibition of γ-aminobutyric acid (GABA) transaminase. Since June 1997 several articles have been published reporting visual field constriction in adult patients on vigabatrin therapy. Recently, 7 pediatric patients, 1 on vigabatrin monotherapy and 6 on add-on therapy with visual field constriction have been described. We have observed 30 pediatric patients with epilepsy (14 boys and 16 girls), ages ranging from 4 to 20 years (mean: 11 years and 2 months) treated with vigabatrin for infantile spasms, simple and complex partial epilepsy, who had never complained of ophthalmologic disturbances. Twenty-one patients underwent complete routine ophthalmologic examination (fundus oculi, visual acuity, intraocular pressure, and visual field tests); 9 children (
| Original language | English |
|---|---|
| Pages (from-to) | 838-842 |
| Number of pages | 5 |
| Journal | Pediatrics |
| Volume | 106 |
| Issue number | 4 I |
| Publication status | Published - 2000 |
Keywords
- Epilepsy
- Vigabatrin
- Visual field
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health