Visual field constriction in children with epilepsy on vigabatrin treatment

Paola Iannetti, Alberto Spalice, Francesco Massimo Perla, Elena Conicella, Umberto Raucci, Barbara Bizzarri

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Abstract

Vigabatrin is considered the drug of choice for infantile spasms and simple and complex partial epilepsy in childhood. Its mechanism of action relies on the irreversible inhibition of γ-aminobutyric acid (GABA) transaminase. Since June 1997 several articles have been published reporting visual field constriction in adult patients on vigabatrin therapy. Recently, 7 pediatric patients, 1 on vigabatrin monotherapy and 6 on add-on therapy with visual field constriction have been described. We have observed 30 pediatric patients with epilepsy (14 boys and 16 girls), ages ranging from 4 to 20 years (mean: 11 years and 2 months) treated with vigabatrin for infantile spasms, simple and complex partial epilepsy, who had never complained of ophthalmologic disturbances. Twenty-one patients underwent complete routine ophthalmologic examination (fundus oculi, visual acuity, intraocular pressure, and visual field tests); 9 children (

Original languageEnglish
Pages (from-to)838-842
Number of pages5
JournalPediatrics
Volume106
Issue number4 I
Publication statusPublished - 2000

Keywords

  • Epilepsy
  • Vigabatrin
  • Visual field

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Iannetti, P., Spalice, A., Perla, F. M., Conicella, E., Raucci, U., & Bizzarri, B. (2000). Visual field constriction in children with epilepsy on vigabatrin treatment. Pediatrics, 106(4 I), 838-842.