Abstract
Vigabatrin is considered the drug of choice for infantile spasms and simple and complex partial epilepsy in childhood. Its mechanism of action relies on the irreversible inhibition of γ-aminobutyric acid (GABA) transaminase. Since June 1997 several articles have been published reporting visual field constriction in adult patients on vigabatrin therapy. Recently, 7 pediatric patients, 1 on vigabatrin monotherapy and 6 on add-on therapy with visual field constriction have been described. We have observed 30 pediatric patients with epilepsy (14 boys and 16 girls), ages ranging from 4 to 20 years (mean: 11 years and 2 months) treated with vigabatrin for infantile spasms, simple and complex partial epilepsy, who had never complained of ophthalmologic disturbances. Twenty-one patients underwent complete routine ophthalmologic examination (fundus oculi, visual acuity, intraocular pressure, and visual field tests); 9 children (
| Original language | English |
|---|---|
| Pages (from-to) | 838-842 |
| Number of pages | 5 |
| Journal | Pediatrics |
| Volume | 106 |
| Issue number | 4 I |
| Publication status | Published - 2000 |
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Keywords
- Epilepsy
- Vigabatrin
- Visual field
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Visual field constriction in children with epilepsy on vigabatrin treatment. / Iannetti, Paola; Spalice, Alberto; Perla, Francesco Massimo; Conicella, Elena; Raucci, Umberto; Bizzarri, Barbara.
In: Pediatrics, Vol. 106, No. 4 I, 2000, p. 838-842.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Visual field constriction in children with epilepsy on vigabatrin treatment
AU - Iannetti, Paola
AU - Spalice, Alberto
AU - Perla, Francesco Massimo
AU - Conicella, Elena
AU - Raucci, Umberto
AU - Bizzarri, Barbara
PY - 2000
Y1 - 2000
N2 - Vigabatrin is considered the drug of choice for infantile spasms and simple and complex partial epilepsy in childhood. Its mechanism of action relies on the irreversible inhibition of γ-aminobutyric acid (GABA) transaminase. Since June 1997 several articles have been published reporting visual field constriction in adult patients on vigabatrin therapy. Recently, 7 pediatric patients, 1 on vigabatrin monotherapy and 6 on add-on therapy with visual field constriction have been described. We have observed 30 pediatric patients with epilepsy (14 boys and 16 girls), ages ranging from 4 to 20 years (mean: 11 years and 2 months) treated with vigabatrin for infantile spasms, simple and complex partial epilepsy, who had never complained of ophthalmologic disturbances. Twenty-one patients underwent complete routine ophthalmologic examination (fundus oculi, visual acuity, intraocular pressure, and visual field tests); 9 children (
AB - Vigabatrin is considered the drug of choice for infantile spasms and simple and complex partial epilepsy in childhood. Its mechanism of action relies on the irreversible inhibition of γ-aminobutyric acid (GABA) transaminase. Since June 1997 several articles have been published reporting visual field constriction in adult patients on vigabatrin therapy. Recently, 7 pediatric patients, 1 on vigabatrin monotherapy and 6 on add-on therapy with visual field constriction have been described. We have observed 30 pediatric patients with epilepsy (14 boys and 16 girls), ages ranging from 4 to 20 years (mean: 11 years and 2 months) treated with vigabatrin for infantile spasms, simple and complex partial epilepsy, who had never complained of ophthalmologic disturbances. Twenty-one patients underwent complete routine ophthalmologic examination (fundus oculi, visual acuity, intraocular pressure, and visual field tests); 9 children (
KW - Epilepsy
KW - Vigabatrin
KW - Visual field
UR - http://www.scopus.com/inward/record.url?scp=0033772632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033772632&partnerID=8YFLogxK
M3 - Article
C2 - 11015531
AN - SCOPUS:0033772632
VL - 106
SP - 838
EP - 842
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 4 I
ER -