Visual field constriction in children with epilepsy on vigabatrin treatment

Paola Iannetti, Alberto Spalice, Francesco Massimo Perla, Elena Conicella, Umberto Raucci, Barbara Bizzarri

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Vigabatrin is considered the drug of choice for infantile spasms and simple and complex partial epilepsy in childhood. Its mechanism of action relies on the irreversible inhibition of γ-aminobutyric acid (GABA) transaminase. Since June 1997 several articles have been published reporting visual field constriction in adult patients on vigabatrin therapy. Recently, 7 pediatric patients, 1 on vigabatrin monotherapy and 6 on add-on therapy with visual field constriction have been described. We have observed 30 pediatric patients with epilepsy (14 boys and 16 girls), ages ranging from 4 to 20 years (mean: 11 years and 2 months) treated with vigabatrin for infantile spasms, simple and complex partial epilepsy, who had never complained of ophthalmologic disturbances. Twenty-one patients underwent complete routine ophthalmologic examination (fundus oculi, visual acuity, intraocular pressure, and visual field tests); 9 children (

Original languageEnglish
Pages (from-to)838-842
Number of pages5
JournalPediatrics
Volume106
Issue number4 I
Publication statusPublished - 2000

Fingerprint

Vigabatrin
Visual Fields
Constriction
Epilepsy
Complex Partial Epilepsy
Infantile Spasms
Partial Epilepsy
Fundus Oculi
4-Aminobutyrate Transaminase
Pediatrics
Aminobutyrates
Visual Field Tests
Therapeutics
Intraocular Pressure
Visual Acuity
Pharmaceutical Preparations

Keywords

  • Epilepsy
  • Vigabatrin
  • Visual field

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Iannetti, P., Spalice, A., Perla, F. M., Conicella, E., Raucci, U., & Bizzarri, B. (2000). Visual field constriction in children with epilepsy on vigabatrin treatment. Pediatrics, 106(4 I), 838-842.

Visual field constriction in children with epilepsy on vigabatrin treatment. / Iannetti, Paola; Spalice, Alberto; Perla, Francesco Massimo; Conicella, Elena; Raucci, Umberto; Bizzarri, Barbara.

In: Pediatrics, Vol. 106, No. 4 I, 2000, p. 838-842.

Research output: Contribution to journalArticle

Iannetti, P, Spalice, A, Perla, FM, Conicella, E, Raucci, U & Bizzarri, B 2000, 'Visual field constriction in children with epilepsy on vigabatrin treatment', Pediatrics, vol. 106, no. 4 I, pp. 838-842.
Iannetti P, Spalice A, Perla FM, Conicella E, Raucci U, Bizzarri B. Visual field constriction in children with epilepsy on vigabatrin treatment. Pediatrics. 2000;106(4 I):838-842.
Iannetti, Paola ; Spalice, Alberto ; Perla, Francesco Massimo ; Conicella, Elena ; Raucci, Umberto ; Bizzarri, Barbara. / Visual field constriction in children with epilepsy on vigabatrin treatment. In: Pediatrics. 2000 ; Vol. 106, No. 4 I. pp. 838-842.
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