Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

Eliana Rulli, Luciano Quaranta, Ivano Riva, Davide Poli, Lital Hollander, Fabio Galli, Andreas Katsanos, Francesco Oddone, Valter Torri, Robert N. Weinreb, L. Varano, T. Carchedi, S. Talarico, F. Parravano, I. Motolese, S. A. Bagaglia, G. C.M. Rossi, S. Lateri, L. Bossolesi, L. CarmassiT. Rolle, R. Piccini, R. Ratiglia, A. Rossi, S. Gandolfi, V. Tagliavini, N. Ungaro, M. Fossarello, A. Cucca, I. Zucca, M. Uva, E. Bonacci, G. Cardarella, D. Tognetto, O. Vattovani, P. Vallon, F. Iannacone, L. Fontana, S. Marchi, G. L. Manni, D. Jannetta, G. Roberti, L. Rossetti, E. Maggiolo, O. Oneta, C. Sborgia, F. Cantatore, L. Mastropasqua, L. Agnifili, E. Campos, C. Gizzi, G. Giannaccare, V. Pucci, M. Cassamali, C. Costagliola, C. Traverso, R. Scotto, M. Musolino, L. Landi, A. Bagnis

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Abstract

The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or "glaucoma suspect" patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were classified as having VF damage in one eye (VFD-1), both eyes (VFD-2), or neither eye (VFD-0). 3227 patients were enrolled and 2940 were eligible for the analysis. 13.4% of patients were classified in the VFD-0, 23.7% in the VFD-1, and 62.9% in the VFD-2 group. GSS visual symptoms domain (Func-4) and GSS non-visual symptoms domain (Symp-6) scores were similar for the VFD-0 and VFD-1 groups (p = 0.133 and p = 0.834 for Func-4 and Symp-6, respectively). VFD-0 group had higher scores than VFD-2 both in Func-4 (p < 0.001) and Symp-6 domains (p = 0.035). Regarding the NEI-VFQ-25, our data demonstrated that bilateral VF defects are associated with vision-related QoL deterioration, irrespective of visual acuity.

Original languageEnglish
Article number619
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

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Visual Fields
Glaucoma
Quality of Life
National Eye Institute (U.S.)
Ocular Hypertension
Visual Acuity
Primary Open Angle Glaucoma

ASJC Scopus subject areas

  • General

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Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study. / Rulli, Eliana; Quaranta, Luciano; Riva, Ivano; Poli, Davide; Hollander, Lital; Galli, Fabio; Katsanos, Andreas; Oddone, Francesco; Torri, Valter; Weinreb, Robert N.; Varano, L.; Carchedi, T.; Talarico, S.; Parravano, F.; Motolese, I.; Bagaglia, S. A.; Rossi, G. C.M.; Lateri, S.; Bossolesi, L.; Carmassi, L.; Rolle, T.; Piccini, R.; Ratiglia, R.; Rossi, A.; Gandolfi, S.; Tagliavini, V.; Ungaro, N.; Fossarello, M.; Cucca, A.; Zucca, I.; Uva, M.; Bonacci, E.; Cardarella, G.; Tognetto, D.; Vattovani, O.; Vallon, P.; Iannacone, F.; Fontana, L.; Marchi, S.; Manni, G. L.; Jannetta, D.; Roberti, G.; Rossetti, L.; Maggiolo, E.; Oneta, O.; Sborgia, C.; Cantatore, F.; Mastropasqua, L.; Agnifili, L.; Campos, E.; Gizzi, C.; Giannaccare, G.; Pucci, V.; Cassamali, M.; Costagliola, C.; Traverso, C.; Scotto, R.; Musolino, M.; Landi, L.; Bagnis, A.

In: Scientific Reports, Vol. 8, No. 1, 619, 01.12.2018.

Research output: Contribution to journalArticle

Rulli, E, Quaranta, L, Riva, I, Poli, D, Hollander, L, Galli, F, Katsanos, A, Oddone, F, Torri, V, Weinreb, RN, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, SA, Rossi, GCM, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, V, Ungaro, N, Fossarello, M, Cucca, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, GL, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, V, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L & Bagnis, A 2018, 'Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study', Scientific Reports, vol. 8, no. 1, 619. https://doi.org/10.1038/s41598-017-19113-z
Rulli, Eliana ; Quaranta, Luciano ; Riva, Ivano ; Poli, Davide ; Hollander, Lital ; Galli, Fabio ; Katsanos, Andreas ; Oddone, Francesco ; Torri, Valter ; Weinreb, Robert N. ; Varano, L. ; Carchedi, T. ; Talarico, S. ; Parravano, F. ; Motolese, I. ; Bagaglia, S. A. ; Rossi, G. C.M. ; Lateri, S. ; Bossolesi, L. ; Carmassi, L. ; Rolle, T. ; Piccini, R. ; Ratiglia, R. ; Rossi, A. ; Gandolfi, S. ; Tagliavini, V. ; Ungaro, N. ; Fossarello, M. ; Cucca, A. ; Zucca, I. ; Uva, M. ; Bonacci, E. ; Cardarella, G. ; Tognetto, D. ; Vattovani, O. ; Vallon, P. ; Iannacone, F. ; Fontana, L. ; Marchi, S. ; Manni, G. L. ; Jannetta, D. ; Roberti, G. ; Rossetti, L. ; Maggiolo, E. ; Oneta, O. ; Sborgia, C. ; Cantatore, F. ; Mastropasqua, L. ; Agnifili, L. ; Campos, E. ; Gizzi, C. ; Giannaccare, G. ; Pucci, V. ; Cassamali, M. ; Costagliola, C. ; Traverso, C. ; Scotto, R. ; Musolino, M. ; Landi, L. ; Bagnis, A. / Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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abstract = "The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or {"}glaucoma suspect{"} patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were classified as having VF damage in one eye (VFD-1), both eyes (VFD-2), or neither eye (VFD-0). 3227 patients were enrolled and 2940 were eligible for the analysis. 13.4{\%} of patients were classified in the VFD-0, 23.7{\%} in the VFD-1, and 62.9{\%} in the VFD-2 group. GSS visual symptoms domain (Func-4) and GSS non-visual symptoms domain (Symp-6) scores were similar for the VFD-0 and VFD-1 groups (p = 0.133 and p = 0.834 for Func-4 and Symp-6, respectively). VFD-0 group had higher scores than VFD-2 both in Func-4 (p < 0.001) and Symp-6 domains (p = 0.035). Regarding the NEI-VFQ-25, our data demonstrated that bilateral VF defects are associated with vision-related QoL deterioration, irrespective of visual acuity.",
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T1 - Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

AU - Rulli, Eliana

AU - Quaranta, Luciano

AU - Riva, Ivano

AU - Poli, Davide

AU - Hollander, Lital

AU - Galli, Fabio

AU - Katsanos, Andreas

AU - Oddone, Francesco

AU - Torri, Valter

AU - Weinreb, Robert N.

AU - Varano, L.

AU - Carchedi, T.

AU - Talarico, S.

AU - Parravano, F.

AU - Motolese, I.

AU - Bagaglia, S. A.

AU - Rossi, G. C.M.

AU - Lateri, S.

AU - Bossolesi, L.

AU - Carmassi, L.

AU - Rolle, T.

AU - Piccini, R.

AU - Ratiglia, R.

AU - Rossi, A.

AU - Gandolfi, S.

AU - Tagliavini, V.

AU - Ungaro, N.

AU - Fossarello, M.

AU - Cucca, A.

AU - Zucca, I.

AU - Uva, M.

AU - Bonacci, E.

AU - Cardarella, G.

AU - Tognetto, D.

AU - Vattovani, O.

AU - Vallon, P.

AU - Iannacone, F.

AU - Fontana, L.

AU - Marchi, S.

AU - Manni, G. L.

AU - Jannetta, D.

AU - Roberti, G.

AU - Rossetti, L.

AU - Maggiolo, E.

AU - Oneta, O.

AU - Sborgia, C.

AU - Cantatore, F.

AU - Mastropasqua, L.

AU - Agnifili, L.

AU - Campos, E.

AU - Gizzi, C.

AU - Giannaccare, G.

AU - Pucci, V.

AU - Cassamali, M.

AU - Costagliola, C.

AU - Traverso, C.

AU - Scotto, R.

AU - Musolino, M.

AU - Landi, L.

AU - Bagnis, A.

PY - 2018/12/1

Y1 - 2018/12/1

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AB - The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or "glaucoma suspect" patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were classified as having VF damage in one eye (VFD-1), both eyes (VFD-2), or neither eye (VFD-0). 3227 patients were enrolled and 2940 were eligible for the analysis. 13.4% of patients were classified in the VFD-0, 23.7% in the VFD-1, and 62.9% in the VFD-2 group. GSS visual symptoms domain (Func-4) and GSS non-visual symptoms domain (Symp-6) scores were similar for the VFD-0 and VFD-1 groups (p = 0.133 and p = 0.834 for Func-4 and Symp-6, respectively). VFD-0 group had higher scores than VFD-2 both in Func-4 (p < 0.001) and Symp-6 domains (p = 0.035). Regarding the NEI-VFQ-25, our data demonstrated that bilateral VF defects are associated with vision-related QoL deterioration, irrespective of visual acuity.

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