Visual function assessment in simulated real-life situations in patients with age-related macular degeneration compared to normal subjects

G. Barteselli, M. L. Gomez, A. L. Doede, J. Chhablani, W. Gutstein, D. U. Bartsch, L. Dustin, S. P. Azen, W. R. Freeman

Research output: Contribution to journalArticle

Abstract

PURPOSE: To evaluate visual function variations in eyes with age-related macular degeneration (AMD) compared to normal eyes under different light/contrast conditions using a time-dependent visual acuity testing instrument, the Central Vision Analyzer (CVA).

METHODS: Overall, 37 AMD eyes and 35 normal eyes were consecutively tested with the CVA after assessing best-corrected visual acuity (BCVA) using ETDRS charts. The CVA established visual thresholds for three mesopic environments (M1 (high contrast), M2 (medium contrast), and M3 (low contrast)) and three backlight-glare environments (G1 (high contrast, equivalent to ETDRS), G2 (medium contrast), and G3 (low contrast)) under timed conditions. Vision drop across environments was calculated, and repeatability of visual scores was determined.

RESULTS: BCVA significantly reduced with decreasing contrast in all eyes. M1 scores for BCVA were greater than M2 and M3 (P

CONCLUSION: The CVA allowed analysis of the visual complaints that AMD patients experience with different lighting/contrast time-dependent conditions. BCVA changed significantly under different lighting/contrast conditions in all eyes, however, AMD eyes were more affected by contrast reduction than normal eyes. In AMD eyes, timed conditions using the CVA led to worse BCVA compared to non-timed ETDRS charts.

Original languageEnglish
Pages (from-to)1231-1238
Number of pages8
JournalEye (London, England)
Volume28
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Barteselli, G., Gomez, M. L., Doede, A. L., Chhablani, J., Gutstein, W., Bartsch, D. U., Dustin, L., Azen, S. P., & Freeman, W. R. (2014). Visual function assessment in simulated real-life situations in patients with age-related macular degeneration compared to normal subjects. Eye (London, England), 28(10), 1231-1238. https://doi.org/10.1038/eye.2014.189