TY - JOUR
T1 - Visual function in menopause
T2 - The role of hormone replacement therapy
AU - Guaschino, Secondo
AU - Grimaldi, Eva
AU - Sartore, Andrea
AU - Mugittu, Raffaela
AU - Mangino, Francesco
AU - Bortoli, Paolo
AU - Pensiero, Stefano
AU - Vinciguerra, Agatino
AU - Perissutti, Paolo
PY - 2003/1
Y1 - 2003/1
N2 - Objective: To assess the effects of hormone replacement therapy (HRT) on visual function after menopause. Design: This study was conducted on 80 postmenopausal women aged 52 to 70 years. Women were randomly divided into two groups: 40 women were treated by oral HRT (equine conjugated estrogens 0.625 mg/day + dydrogesterone 5 mg/day in a continuous combined regimen), and 40 women were not treated with hormones (control group). Each woman underwent a contrast sensitivity test, a Schirmer test, and an evaluation of intraocular pressure before starting the study and 1 year after the beginning of the study. Statistical analysis was performed by Student's t test and Fisher's exact test. Results: Contrast sensitivity function was significantly improved in all spatial frequencies (1.5, 3, 6, and 12 cycles per degree) with the exception of 18 cycles per degree in the HRT group 1 year after the beginning of treatment, whereas the control group demonstrated significant impairment at the lowest spatial frequencies (1.5, 3, and 6 cycles per degree). Tear production was significantly improved in the HRT group 1 year after the beginning of treatment, and intraocular pressure was similar in the two groups before and after the beginning of the study. Conclusions: HRT improves visual function, promoting a better contrast sensitivity and a higher tear production, but does not modify intraocular pressure.
AB - Objective: To assess the effects of hormone replacement therapy (HRT) on visual function after menopause. Design: This study was conducted on 80 postmenopausal women aged 52 to 70 years. Women were randomly divided into two groups: 40 women were treated by oral HRT (equine conjugated estrogens 0.625 mg/day + dydrogesterone 5 mg/day in a continuous combined regimen), and 40 women were not treated with hormones (control group). Each woman underwent a contrast sensitivity test, a Schirmer test, and an evaluation of intraocular pressure before starting the study and 1 year after the beginning of the study. Statistical analysis was performed by Student's t test and Fisher's exact test. Results: Contrast sensitivity function was significantly improved in all spatial frequencies (1.5, 3, 6, and 12 cycles per degree) with the exception of 18 cycles per degree in the HRT group 1 year after the beginning of treatment, whereas the control group demonstrated significant impairment at the lowest spatial frequencies (1.5, 3, and 6 cycles per degree). Tear production was significantly improved in the HRT group 1 year after the beginning of treatment, and intraocular pressure was similar in the two groups before and after the beginning of the study. Conclusions: HRT improves visual function, promoting a better contrast sensitivity and a higher tear production, but does not modify intraocular pressure.
KW - Contrast sensitivity
KW - Hormone replacement therapy
KW - Intraocular pressure
KW - Menopause
KW - Tear secretion
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U2 - 10.1097/00042192-200310010-00009
DO - 10.1097/00042192-200310010-00009
M3 - Article
C2 - 12544677
AN - SCOPUS:0037507409
VL - 10
SP - 53
EP - 57
JO - Menopause
JF - Menopause
SN - 1072-3714
IS - 1
ER -