Visual processing in Noonan syndrome: Dorsal and ventral stream sensitivity

Paolo Alfieri, Laura Cesarini, Paola De Rose, Daniela Ricci, Angelo Selicorni, Deny Menghini, Andrea Guzzetta, Giovanni Baranello, Francesca Tinelli, Maria Mallardi, Giuseppe Zampino, Stefano Vicari, Janette Atkinson, Eugenio Mercuri

Research output: Contribution to journalArticlepeer-review


Global spatial and motion processing abilities were assessed in 18 patients with Noonan syndrome (NS) and in 43 matched controls using form and motion coherence testing, respectively. We observed a discrepancy between the two groups since the study group had significantly lower performances than the control group for form coherence while there was no impairment on motion coherence. All the patients were also assessed on the Movement Assessment Battery for Children (M-ABC) to evaluate visuomotor skills. Thirteen of the 18 (72%) also had global poor performances on the M-ABC. The results show that children with NS have a specific impairment in the global processing of visuospatial information and are likely to have a specific ventral stream deficit as also suggested by the frequent visuomotor perceptual difficulties. Testing form and motion coherence thresholds may be a useful diagnostic tool for this group of patients, despite their normal cognitive abilities, since aspects of global form processing and visuomotor perceptual difficulties can be identified and potentially targeted for a specific rehabilitation program.

Original languageEnglish
Pages (from-to)2459-2464
Number of pages6
JournalAmerican Journal of Medical Genetics, Part A
Issue number10
Publication statusPublished - Oct 2011


  • Dorsal stream
  • Noonan syndrome
  • Ventral stream
  • Visual processing
  • Visuomotor skills

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics


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