Visualization and modelling of STLmax topographic brain activity maps

Nadia Mammone, José C. Principe, Francesco C. Morabito, Deng S. Shiau, J. Chris Sackellares

Research output: Contribution to journalArticle

Abstract

This paper evaluates the descriptive power of brain topography based on a dynamical parameter, the Short-Term Maximum Lyapunov Exponent (STLmax), estimated from EEG, for finding out a relationship of STLmax spatial distribution with the onset zone and with the mechanisms leading to epileptic seizures. Our preliminary work showed that visual assessment of STLmax topography exhibited a link with the location of seizure onset zone. The objective of the present work is to model the spatial distribution of STLmax in order to automatically extract these features from the maps. One-hour preictal segments from four long-term continuous EEG recordings (two scalp and two intracranial) were processed and the corresponding STLmax profiles were estimated. The spatial STLmax maps were modelled by a combination of two Gaussians functions. The parameters of the fitted model allow automatic extraction of quantitative information about the spatial distribution of STLmax: the EEG signal recorded from the brain region where seizures originate exhibited low-STLmax levels, long before the seizure onset, in 3 out of 4 patients (1 out of 2 of scalp patients and 2 out of 2 in intracranial patients). Topographic maps extracted directly from the EEG power did not provide useful information about the location, therefore we conclude that the analysis so far carried out suggests the possibility of using a model of STLmax topography as a tool for monitoring the evolution of epileptic brain dynamics. In the future, a more elaborate approach will be investigated in order to improve the specificity of the method.

Original languageEnglish
Pages (from-to)281-294
Number of pages14
JournalJournal of Neuroscience Methods
Volume189
Issue number2
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Electroencephalography
Seizures
Brain
Scalp
Information Storage and Retrieval
Epilepsy

Keywords

  • Brain mapping
  • Electroencephalography
  • Gaussian modelling
  • STLmax

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Mammone, N., Principe, J. C., Morabito, F. C., Shiau, D. S., & Sackellares, J. C. (2010). Visualization and modelling of STLmax topographic brain activity maps. Journal of Neuroscience Methods, 189(2), 281-294. https://doi.org/10.1016/j.jneumeth.2010.03.027

Visualization and modelling of STLmax topographic brain activity maps. / Mammone, Nadia; Principe, José C.; Morabito, Francesco C.; Shiau, Deng S.; Sackellares, J. Chris.

In: Journal of Neuroscience Methods, Vol. 189, No. 2, 06.2010, p. 281-294.

Research output: Contribution to journalArticle

Mammone, N, Principe, JC, Morabito, FC, Shiau, DS & Sackellares, JC 2010, 'Visualization and modelling of STLmax topographic brain activity maps', Journal of Neuroscience Methods, vol. 189, no. 2, pp. 281-294. https://doi.org/10.1016/j.jneumeth.2010.03.027
Mammone, Nadia ; Principe, José C. ; Morabito, Francesco C. ; Shiau, Deng S. ; Sackellares, J. Chris. / Visualization and modelling of STLmax topographic brain activity maps. In: Journal of Neuroscience Methods. 2010 ; Vol. 189, No. 2. pp. 281-294.
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