Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6

Jörg B. Schulz, Johannes Borkert, Stefanie Wolf, Tanja Schmitz-Hübsch, Maryla Rakowicz, Caterina Mariotti, Ludger Schoels, Dagmar Timmann, Bart van de Warrenburg, Alexandra Dürr, Massimo Pandolfo, Jun Suk Kang, Andrés González Mandly, Thomas Nägele, Marina Grisoli, Romana Boguslawska, Peter Bauer, Thomas Klockgether, Till Karsten Hauser

Research output: Contribution to journalArticle

Abstract

Background and objective: Biomarkers to monitor neurological dysfunction in autosomal dominant inherited spinocerebellar ataxias (SCA) are lacking. We therefore aimed to visualize, quantify and correlate localized brain atrophy with clinical symptoms in SCA1, SCA3, and SCA6. Methods: We compared patients suffering from SCA1 (n = 48), SCA3 (n = 24), and SCA6 (n = 10) with 32 controls using magnetic resonance imaging (MRI) on four different scanners in eight centers followed by voxel-based morphometry (VBM) and quantitative three-dimensional (3D) volumetry. Results: SCA1 and SCA3 patients presented with severe atrophy in total brainstem (consisting of midbrain, pons, and medulla), pons, medulla, total cerebellum, cerebellar hemispheres and cerebellar vermis, putamen and caudate nucleus. Atrophy in the cerebellar hemispheres was less severe in SCA3 than in SCA1 and SCA6. Atrophy in SCA6 was restricted to the grey matter of the cerebellum (VBM and volumetry), total brainstem and pons (volumetry only). Overall, we did not observe substantial atrophy in the cerebral cortex. A discriminant analysis taking into account data from pons, cerebellar hemispheres, medulla, midbrain and putamen achieved a reclassification probability of 81.7% for SCA1, SCA3, and SCA6. The repeat length of the expanded allele showed a weak negative correlation with the volume of the brainstem, pons, caudate nucleus and putamen in SCA3, and a weak correlation with the pons in SCA1, whereas no such correlation was found in SCA6. Clinical dysfunction as measured by the Scale for the Assessment and Rating of Ataxia (SARA) and the Unified Huntington's Disease Rating Scale functional assessment correlated best with the atrophy of pons in SCA1, with total brainstem atrophy in SCA3 and atrophy of total cerebellum in SCA6. Conclusions: Our data provide strong evidence that MRI is an attractive surrogate marker for clinical studies of SCA. In each SCA genotype clinical dysfunction may be caused by different patho-anatomical processes.

Original languageEnglish
Pages (from-to)158-168
Number of pages11
JournalNeuroImage
Volume49
Issue number1
DOIs
Publication statusPublished - Jan 1 2010

Keywords

  • Repeat length
  • Spinocerebellar ataxia
  • Volumetry
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

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    Schulz, J. B., Borkert, J., Wolf, S., Schmitz-Hübsch, T., Rakowicz, M., Mariotti, C., Schoels, L., Timmann, D., van de Warrenburg, B., Dürr, A., Pandolfo, M., Kang, J. S., Mandly, A. G., Nägele, T., Grisoli, M., Boguslawska, R., Bauer, P., Klockgether, T., & Hauser, T. K. (2010). Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6. NeuroImage, 49(1), 158-168. https://doi.org/10.1016/j.neuroimage.2009.07.027