Vitamin D: A new player in kidney transplantation?

Claudio Ponticelli, Gabriele Sala

Research output: Contribution to journalArticle

Abstract

Vitamin D is a hormone with pleiotropic effects. It mainly regulates calcium and phosphate metabolism through interactions with FGF23 and its receptor klotho. In addition, it has been shown that Vitamin D also regulates the immune response and has protective effects from cardiovascular disease, cancer and infections. Most renal transplant recipients have overt Vitamin D deficiency, a condition that may be associated with a decline in graft function and other complications. After kidney transplantation, elevated levels of FGF23 may predict increased risks of death and allograft loss. Theoretically, an optimal Vitamin D supplementation might favor operational tolerance and protect transplant recipients from the triad cardiovascular disease-cancer-infection. However, more solid data are needed to confirm this and to set the optimal level of serum Vitamin D supplementation in order to attain the best clinical outcome.

Original languageEnglish
Pages (from-to)1375-1383
Number of pages9
JournalExpert Review of Clinical Immunology
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

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Keywords

  • cardiovascular disease
  • immunosuppression
  • rejection
  • renal transplantation
  • vitamin and hormone
  • vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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