Vitamin D

A new player in kidney transplantation?

Claudio Ponticelli, Gabriele Sala

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Vitamin D is a hormone with pleiotropic effects. It mainly regulates calcium and phosphate metabolism through interactions with FGF23 and its receptor klotho. In addition, it has been shown that Vitamin D also regulates the immune response and has protective effects from cardiovascular disease, cancer and infections. Most renal transplant recipients have overt Vitamin D deficiency, a condition that may be associated with a decline in graft function and other complications. After kidney transplantation, elevated levels of FGF23 may predict increased risks of death and allograft loss. Theoretically, an optimal Vitamin D supplementation might favor operational tolerance and protect transplant recipients from the triad cardiovascular disease-cancer-infection. However, more solid data are needed to confirm this and to set the optimal level of serum Vitamin D supplementation in order to attain the best clinical outcome.

Original languageEnglish
Pages (from-to)1375-1383
Number of pages9
JournalExpert Review of Clinical Immunology
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Vitamin D
Kidney Transplantation
Cardiovascular Diseases
Cardiovascular Infections
Vitamin D Deficiency
Allografts
Neoplasms
Hormones
Transplants
Kidney
Infection
Serum
Transplant Recipients

Keywords

  • cardiovascular disease
  • immunosuppression
  • rejection
  • renal transplantation
  • vitamin and hormone
  • vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Vitamin D : A new player in kidney transplantation? / Ponticelli, Claudio; Sala, Gabriele.

In: Expert Review of Clinical Immunology, Vol. 10, No. 10, 01.10.2014, p. 1375-1383.

Research output: Contribution to journalArticle

Ponticelli, Claudio ; Sala, Gabriele. / Vitamin D : A new player in kidney transplantation?. In: Expert Review of Clinical Immunology. 2014 ; Vol. 10, No. 10. pp. 1375-1383.
@article{05839d798091419fbae28bed6b31eb5e,
title = "Vitamin D: A new player in kidney transplantation?",
abstract = "Vitamin D is a hormone with pleiotropic effects. It mainly regulates calcium and phosphate metabolism through interactions with FGF23 and its receptor klotho. In addition, it has been shown that Vitamin D also regulates the immune response and has protective effects from cardiovascular disease, cancer and infections. Most renal transplant recipients have overt Vitamin D deficiency, a condition that may be associated with a decline in graft function and other complications. After kidney transplantation, elevated levels of FGF23 may predict increased risks of death and allograft loss. Theoretically, an optimal Vitamin D supplementation might favor operational tolerance and protect transplant recipients from the triad cardiovascular disease-cancer-infection. However, more solid data are needed to confirm this and to set the optimal level of serum Vitamin D supplementation in order to attain the best clinical outcome.",
keywords = "cardiovascular disease, immunosuppression, rejection, renal transplantation, vitamin and hormone, vitamin D",
author = "Claudio Ponticelli and Gabriele Sala",
year = "2014",
month = "10",
day = "1",
doi = "10.1586/1744666X.2014.949674",
language = "English",
volume = "10",
pages = "1375--1383",
journal = "Expert Review of Clinical Immunology",
issn = "1744-666X",
publisher = "Expert Reviews Ltd.",
number = "10",

}

TY - JOUR

T1 - Vitamin D

T2 - A new player in kidney transplantation?

AU - Ponticelli, Claudio

AU - Sala, Gabriele

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Vitamin D is a hormone with pleiotropic effects. It mainly regulates calcium and phosphate metabolism through interactions with FGF23 and its receptor klotho. In addition, it has been shown that Vitamin D also regulates the immune response and has protective effects from cardiovascular disease, cancer and infections. Most renal transplant recipients have overt Vitamin D deficiency, a condition that may be associated with a decline in graft function and other complications. After kidney transplantation, elevated levels of FGF23 may predict increased risks of death and allograft loss. Theoretically, an optimal Vitamin D supplementation might favor operational tolerance and protect transplant recipients from the triad cardiovascular disease-cancer-infection. However, more solid data are needed to confirm this and to set the optimal level of serum Vitamin D supplementation in order to attain the best clinical outcome.

AB - Vitamin D is a hormone with pleiotropic effects. It mainly regulates calcium and phosphate metabolism through interactions with FGF23 and its receptor klotho. In addition, it has been shown that Vitamin D also regulates the immune response and has protective effects from cardiovascular disease, cancer and infections. Most renal transplant recipients have overt Vitamin D deficiency, a condition that may be associated with a decline in graft function and other complications. After kidney transplantation, elevated levels of FGF23 may predict increased risks of death and allograft loss. Theoretically, an optimal Vitamin D supplementation might favor operational tolerance and protect transplant recipients from the triad cardiovascular disease-cancer-infection. However, more solid data are needed to confirm this and to set the optimal level of serum Vitamin D supplementation in order to attain the best clinical outcome.

KW - cardiovascular disease

KW - immunosuppression

KW - rejection

KW - renal transplantation

KW - vitamin and hormone

KW - vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84907274863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907274863&partnerID=8YFLogxK

U2 - 10.1586/1744666X.2014.949674

DO - 10.1586/1744666X.2014.949674

M3 - Article

VL - 10

SP - 1375

EP - 1383

JO - Expert Review of Clinical Immunology

JF - Expert Review of Clinical Immunology

SN - 1744-666X

IS - 10

ER -