Vitamin D and antiphospholipid syndrome

L. Andreoli, S. Piantoni, F. Dall'Ara, F. Allegri, P. L. Meroni, A. Tincani

Research output: Contribution to journalArticlepeer-review

Abstract

Vitamin D (vitD) has been shown to have multiple immunomodulatory properties. Hypovitaminosis D has been described in many systemic autoimmune diseases. Antiphospholipid syndrome (APS), an autoimmune disease characterized by immune-mediated thrombosis and pregnancy loss, is a peculiar model for studying vitD, since these patients do not usually have a full-blown autoimmune disease, nor do they have particular restrictions regarding sun exposure. We assessed 25-OH vitD levels in 115 APS and 128 normal healthy donors (NHD) with the LIAISON chemiluminescent immunoassay by DiaSorin (Italy). Median values were lower in APS patients than in NHD, with the greatest difference occurring during summertime (p

Original languageEnglish
Pages (from-to)736-740
Number of pages5
JournalLupus
Volume21
Issue number7
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Antinuclear antibodies (ANA)
  • antiphospholipid syndrome (APS)
  • hypovitaminosis D
  • thrombosis
  • vitamin D (vitD)

ASJC Scopus subject areas

  • Rheumatology

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