Vitamin D and cancer

Laura Vuolo, Carolina Di Somma, Antongiulio Faggiano, Annamaria Colao

Research output: Contribution to journalArticle

Abstract

Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes, and receptors. This complex system actives several molecular pathways and mediates a multitude of functions. In addition to the classical role in calcium and bone homeostasis, vitamin D plays "non-calcemic" effects in host defense, inflammation, immunity, and cancer processes as recognized in vitro and in vivo studies. The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing sev-eral mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer. Vitamin D acts like a transcription factor that influences central mechanisms of tumorigenesis: growth, cell differentiation, and apopto-sis. In addition to cellular and molecular studies, epidemiological surveys have shown that sunlight exposure and consequent increased circulating levels of vitamin D are associated with reduced reduced occurrence and a reduced mortality in different histological types of cancer. Another recent field of interest concerns polymorphisms of vitamin D receptor (VDR); in this context, preliminary data suggest that VDR polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1,Taq1, Apa1, EcoRV, Cdx2; although further studies are needed to clarify their role in the cancer. In this review, the relationship between vitamin D and cancer is discussed.

Original languageEnglish
Article numberArticle 58
JournalFrontiers in Endocrinology
Volume3
Issue numberAPR
DOIs
Publication statusPublished - 2012

Fingerprint

Vitamin D
Neoplasms
Calcitriol Receptors
Carcinogenesis
Sunlight
Epidemiologic Studies
Cell Differentiation
Immunity
Homeostasis
Transcription Factors
Inflammation
Calcium
Bone and Bones
Mortality
Enzymes
Growth

Keywords

  • 25-hydroxy-vitamin D
  • Cancer
  • Immunity
  • Inflammation
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Vuolo, L., Di Somma, C., Faggiano, A., & Colao, A. (2012). Vitamin D and cancer. Frontiers in Endocrinology, 3(APR), [Article 58]. https://doi.org/10.3389/fendo.2012.00058

Vitamin D and cancer. / Vuolo, Laura; Di Somma, Carolina; Faggiano, Antongiulio; Colao, Annamaria.

In: Frontiers in Endocrinology, Vol. 3, No. APR, Article 58, 2012.

Research output: Contribution to journalArticle

Vuolo, L, Di Somma, C, Faggiano, A & Colao, A 2012, 'Vitamin D and cancer', Frontiers in Endocrinology, vol. 3, no. APR, Article 58. https://doi.org/10.3389/fendo.2012.00058
Vuolo, Laura ; Di Somma, Carolina ; Faggiano, Antongiulio ; Colao, Annamaria. / Vitamin D and cancer. In: Frontiers in Endocrinology. 2012 ; Vol. 3, No. APR.
@article{0da84af601ac476eaf576f741a145936,
title = "Vitamin D and cancer",
abstract = "Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes, and receptors. This complex system actives several molecular pathways and mediates a multitude of functions. In addition to the classical role in calcium and bone homeostasis, vitamin D plays {"}non-calcemic{"} effects in host defense, inflammation, immunity, and cancer processes as recognized in vitro and in vivo studies. The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing sev-eral mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer. Vitamin D acts like a transcription factor that influences central mechanisms of tumorigenesis: growth, cell differentiation, and apopto-sis. In addition to cellular and molecular studies, epidemiological surveys have shown that sunlight exposure and consequent increased circulating levels of vitamin D are associated with reduced reduced occurrence and a reduced mortality in different histological types of cancer. Another recent field of interest concerns polymorphisms of vitamin D receptor (VDR); in this context, preliminary data suggest that VDR polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1,Taq1, Apa1, EcoRV, Cdx2; although further studies are needed to clarify their role in the cancer. In this review, the relationship between vitamin D and cancer is discussed.",
keywords = "25-hydroxy-vitamin D, Cancer, Immunity, Inflammation, Vitamin D",
author = "Laura Vuolo and {Di Somma}, Carolina and Antongiulio Faggiano and Annamaria Colao",
year = "2012",
doi = "10.3389/fendo.2012.00058",
language = "English",
volume = "3",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S. A.",
number = "APR",

}

TY - JOUR

T1 - Vitamin D and cancer

AU - Vuolo, Laura

AU - Di Somma, Carolina

AU - Faggiano, Antongiulio

AU - Colao, Annamaria

PY - 2012

Y1 - 2012

N2 - Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes, and receptors. This complex system actives several molecular pathways and mediates a multitude of functions. In addition to the classical role in calcium and bone homeostasis, vitamin D plays "non-calcemic" effects in host defense, inflammation, immunity, and cancer processes as recognized in vitro and in vivo studies. The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing sev-eral mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer. Vitamin D acts like a transcription factor that influences central mechanisms of tumorigenesis: growth, cell differentiation, and apopto-sis. In addition to cellular and molecular studies, epidemiological surveys have shown that sunlight exposure and consequent increased circulating levels of vitamin D are associated with reduced reduced occurrence and a reduced mortality in different histological types of cancer. Another recent field of interest concerns polymorphisms of vitamin D receptor (VDR); in this context, preliminary data suggest that VDR polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1,Taq1, Apa1, EcoRV, Cdx2; although further studies are needed to clarify their role in the cancer. In this review, the relationship between vitamin D and cancer is discussed.

AB - Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes, and receptors. This complex system actives several molecular pathways and mediates a multitude of functions. In addition to the classical role in calcium and bone homeostasis, vitamin D plays "non-calcemic" effects in host defense, inflammation, immunity, and cancer processes as recognized in vitro and in vivo studies. The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing sev-eral mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer. Vitamin D acts like a transcription factor that influences central mechanisms of tumorigenesis: growth, cell differentiation, and apopto-sis. In addition to cellular and molecular studies, epidemiological surveys have shown that sunlight exposure and consequent increased circulating levels of vitamin D are associated with reduced reduced occurrence and a reduced mortality in different histological types of cancer. Another recent field of interest concerns polymorphisms of vitamin D receptor (VDR); in this context, preliminary data suggest that VDR polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1,Taq1, Apa1, EcoRV, Cdx2; although further studies are needed to clarify their role in the cancer. In this review, the relationship between vitamin D and cancer is discussed.

KW - 25-hydroxy-vitamin D

KW - Cancer

KW - Immunity

KW - Inflammation

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84870796446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870796446&partnerID=8YFLogxK

U2 - 10.3389/fendo.2012.00058

DO - 10.3389/fendo.2012.00058

M3 - Article

C2 - 22649423

AN - SCOPUS:84870796446

VL - 3

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

IS - APR

M1 - Article 58

ER -