Abstract
Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes, and receptors. This complex system actives several molecular pathways and mediates a multitude of functions. In addition to the classical role in calcium and bone homeostasis, vitamin D plays "non-calcemic" effects in host defense, inflammation, immunity, and cancer processes as recognized in vitro and in vivo studies. The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing sev-eral mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer. Vitamin D acts like a transcription factor that influences central mechanisms of tumorigenesis: growth, cell differentiation, and apopto-sis. In addition to cellular and molecular studies, epidemiological surveys have shown that sunlight exposure and consequent increased circulating levels of vitamin D are associated with reduced reduced occurrence and a reduced mortality in different histological types of cancer. Another recent field of interest concerns polymorphisms of vitamin D receptor (VDR); in this context, preliminary data suggest that VDR polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1,Taq1, Apa1, EcoRV, Cdx2; although further studies are needed to clarify their role in the cancer. In this review, the relationship between vitamin D and cancer is discussed.
| Original language | English |
|---|---|
| Article number | Article 58 |
| Journal | Frontiers in Endocrinology |
| Volume | 3 |
| Issue number | APR |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- 25-hydroxy-vitamin D
- Cancer
- Immunity
- Inflammation
- Vitamin D
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
Cite this
Vitamin D and cancer. / Vuolo, Laura; Di Somma, Carolina; Faggiano, Antongiulio; Colao, Annamaria.
In: Frontiers in Endocrinology, Vol. 3, No. APR, Article 58, 2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin D and cancer
AU - Vuolo, Laura
AU - Di Somma, Carolina
AU - Faggiano, Antongiulio
AU - Colao, Annamaria
PY - 2012
Y1 - 2012
N2 - Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes, and receptors. This complex system actives several molecular pathways and mediates a multitude of functions. In addition to the classical role in calcium and bone homeostasis, vitamin D plays "non-calcemic" effects in host defense, inflammation, immunity, and cancer processes as recognized in vitro and in vivo studies. The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing sev-eral mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer. Vitamin D acts like a transcription factor that influences central mechanisms of tumorigenesis: growth, cell differentiation, and apopto-sis. In addition to cellular and molecular studies, epidemiological surveys have shown that sunlight exposure and consequent increased circulating levels of vitamin D are associated with reduced reduced occurrence and a reduced mortality in different histological types of cancer. Another recent field of interest concerns polymorphisms of vitamin D receptor (VDR); in this context, preliminary data suggest that VDR polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1,Taq1, Apa1, EcoRV, Cdx2; although further studies are needed to clarify their role in the cancer. In this review, the relationship between vitamin D and cancer is discussed.
AB - Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes, and receptors. This complex system actives several molecular pathways and mediates a multitude of functions. In addition to the classical role in calcium and bone homeostasis, vitamin D plays "non-calcemic" effects in host defense, inflammation, immunity, and cancer processes as recognized in vitro and in vivo studies. The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing sev-eral mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer. Vitamin D acts like a transcription factor that influences central mechanisms of tumorigenesis: growth, cell differentiation, and apopto-sis. In addition to cellular and molecular studies, epidemiological surveys have shown that sunlight exposure and consequent increased circulating levels of vitamin D are associated with reduced reduced occurrence and a reduced mortality in different histological types of cancer. Another recent field of interest concerns polymorphisms of vitamin D receptor (VDR); in this context, preliminary data suggest that VDR polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1,Taq1, Apa1, EcoRV, Cdx2; although further studies are needed to clarify their role in the cancer. In this review, the relationship between vitamin D and cancer is discussed.
KW - 25-hydroxy-vitamin D
KW - Cancer
KW - Immunity
KW - Inflammation
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84870796446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870796446&partnerID=8YFLogxK
U2 - 10.3389/fendo.2012.00058
DO - 10.3389/fendo.2012.00058
M3 - Article
C2 - 22649423
AN - SCOPUS:84870796446
VL - 3
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
IS - APR
M1 - Article 58
ER -