Vitamin D and cancer mortality: Systematic review of prospective epidemiological studies

Stefan Pilz, Katharina Kienreich, Andreas Tomaschitz, Eberhard Ritz, Elisabeth Lerchbaum, Barbara Obermayer-Pietsch, Veronika Matzi, Joerg Lindenmann, Winfried März, Sara Gandini, Jacqueline M. Dekker

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Accumulating evidence from experimental and epidemiological studies suggests that vitamin D deficiency might be a causal risk factor for cancer and therewith associated mortality. We performed a systematic review in Medline up to February 2012 to identify prospective studies on 25-hydroxyvitamin D (25[OH]D) and cancer mortality as well as on 25(OH)D and survival in cancer patients. Our search retrieved 13 studies on cancer-specific mortality and 20 studies on overall mortality in cancer patients. Data on 25(OH)D and cancer mortality were mainly derived from general populations. The results were inconsistent and yielded either no, inverse or positive associations. By contrast, the majority of studies in cancer patients showed that patients with higher 25(OH)D levels had a decreased risk of mortality. This relationship was particularly evident in cohorts of colorectal cancer patients. In contrast, there was no indication for increased mortality risk with higher vitamin D levels in any cancer cohort. In conclusion, the relationship of vitamin D status and cancerspecific mortality is still unclear and warrants further studies. Our results provide a strong rationale to perform prospective randomized controlled studies to document a potential effect of vitamin D supplementation on survival in cancer patients.

Original languageEnglish
Pages (from-to)107-117
Number of pages11
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume13
Issue number1
Publication statusPublished - 2013

Fingerprint

Vitamin D
Epidemiologic Studies
Prospective Studies
Mortality
Neoplasms
Vitamin D Deficiency
Survival
Colorectal Neoplasms
Population

Keywords

  • 1
  • 25(OH)2D
  • 25(OH)D
  • Calcidiol
  • Calcitriol
  • Cancer
  • Colorectal cancer
  • Death
  • Epidemiological
  • Follow-up
  • Mortality
  • Outcome
  • Prospective
  • Randomized controlled trial
  • RCT
  • Survival
  • Vitamin D
  • WHI

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pharmacology

Cite this

Pilz, S., Kienreich, K., Tomaschitz, A., Ritz, E., Lerchbaum, E., Obermayer-Pietsch, B., ... Dekker, J. M. (2013). Vitamin D and cancer mortality: Systematic review of prospective epidemiological studies. Anti-Cancer Agents in Medicinal Chemistry, 13(1), 107-117.

Vitamin D and cancer mortality : Systematic review of prospective epidemiological studies. / Pilz, Stefan; Kienreich, Katharina; Tomaschitz, Andreas; Ritz, Eberhard; Lerchbaum, Elisabeth; Obermayer-Pietsch, Barbara; Matzi, Veronika; Lindenmann, Joerg; März, Winfried; Gandini, Sara; Dekker, Jacqueline M.

In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 13, No. 1, 2013, p. 107-117.

Research output: Contribution to journalArticle

Pilz, S, Kienreich, K, Tomaschitz, A, Ritz, E, Lerchbaum, E, Obermayer-Pietsch, B, Matzi, V, Lindenmann, J, März, W, Gandini, S & Dekker, JM 2013, 'Vitamin D and cancer mortality: Systematic review of prospective epidemiological studies', Anti-Cancer Agents in Medicinal Chemistry, vol. 13, no. 1, pp. 107-117.
Pilz S, Kienreich K, Tomaschitz A, Ritz E, Lerchbaum E, Obermayer-Pietsch B et al. Vitamin D and cancer mortality: Systematic review of prospective epidemiological studies. Anti-Cancer Agents in Medicinal Chemistry. 2013;13(1):107-117.
Pilz, Stefan ; Kienreich, Katharina ; Tomaschitz, Andreas ; Ritz, Eberhard ; Lerchbaum, Elisabeth ; Obermayer-Pietsch, Barbara ; Matzi, Veronika ; Lindenmann, Joerg ; März, Winfried ; Gandini, Sara ; Dekker, Jacqueline M. / Vitamin D and cancer mortality : Systematic review of prospective epidemiological studies. In: Anti-Cancer Agents in Medicinal Chemistry. 2013 ; Vol. 13, No. 1. pp. 107-117.
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