Vitamin D and endometrium: A systematic review of a neglected area of research

GC Cermisoni, A Alteri, L Corti, E Rabellotti, E Papaleo, P Viganò, Ana Maria Sanchez

Research output: Contribution to journalArticle

Abstract

Growing evidence supports a role of vitamin D (VD) in reproductive health. Vitamin D receptor (VDR) is expressed in the ovary, endometrium, and myometrium. The biological actions of VD in fertility and reproductive tissues have been investigated but mainly using animal models. Conversely, the molecular data addressing the mechanisms underlying VD action in the physiologic endometrium and in endometrial pathologies are still scant. Levels of VDR expression according to the menstrual cycle are yet to be definitively clarified, possibly being lower in the proliferative compared to the secretory phase and in mid-secretory compared to early secretory phase. Endometrial tissue also expresses the enzymes involved in the metabolism of VD. The potential anti-proliferative and anti-inflammatory effects of VD for the treatment of endometriosis have been investigated in recent years. Treatment of ectopic endometrial cells with 1,25(OH)2D3could significantly reduce cytokine-mediated inflammatory responses. An alteration of VD metabolism in terms of increased 24-hydroxylase mRNA and protein expression has been demonstrated in endometrial cancer, albeit not consistently. The effect of the active form of the vitamin as an anti-proliferative, pro-apoptotic, anti-inflammatory, and differentiation-inducing agent has been demonstrated in various endometrial cancer cell lines. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Original languageEnglish
Article number2320
JournalInternational Journal of Molecular Sciences
Volume19
Issue number8
DOIs
Publication statusPublished - 2018

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calciferol
Vitamins
Endometrium
Vitamin D
Research
Calcitriol Receptors
Endometrial Neoplasms
Metabolism
metabolism
Anti-Inflammatory Agents
Cells
Tissue
Myometrium
cancer
Reproductive Health
Pathology
Endometriosis
Menstrual Cycle
fertility
Mixed Function Oxygenases

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Vitamin D and endometrium: A systematic review of a neglected area of research. / Cermisoni, GC; Alteri, A; Corti, L; Rabellotti, E; Papaleo, E; Viganò, P; Sanchez, Ana Maria.

In: International Journal of Molecular Sciences, Vol. 19, No. 8, 2320, 2018.

Research output: Contribution to journalArticle

Cermisoni, GC ; Alteri, A ; Corti, L ; Rabellotti, E ; Papaleo, E ; Viganò, P ; Sanchez, Ana Maria. / Vitamin D and endometrium: A systematic review of a neglected area of research. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 8.
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