Vitamin D and its metabolites in the pathogenesis and treatment of osteoporosis

Luigi Gennari, Daniela Merlotti, Giuseppe Martini, Fabrizio Valleggi, Vincenzo De Paola, Ranuccio Nuti

Research output: Contribution to journalArticle

Abstract

Vitamin D and calcium are essential for normal skeletal growth and for maintaining the mechanical and structural integrity of the skeleton. Reduced intake of calcium and vitamin D may be associated with reduced bone mass and osteoporosis while a chronic and severe vitamin D deficiency may lead to osteomalacia. 1,25(OH)2D (calcitriol) is the major active metabolite of vitamin D and promotes intestinal calcium absorption and the mineralization of bone matrix and reduces PTH secretion. Despite vitamin D and calcium are considered essential components of management strategies for the prevention and treatment of osteoporosis, many people do not have adequate vitamin D levels. Vitamin D insufficiency is particularly common in the elderly due to reduced exposition to sunlight, declined synthesis of vitamin D in the skin and impaired renal hydroxylation. Even though secure inferences from randomized controlled trials on the prevention of osteoporotic fracture with vitamin D or its metabolites are limited, these compounds have been demonstrated to be pharmacologically active, safe and cost-effective for the prevention of age-related bone loss. Their use should be encouraged expecially in elderly subjects or in condition of dietary deficiencies. Interestingly, health benefits of vitamin D and its analogues may go beyond osteoporosis, including prevention of cancer and autoimmune diseases and improvement of neuromuscular function.

Original languageEnglish
Pages (from-to)23-34
Number of pages12
JournalClinical Cases in Mineral and Bone Metabolism
Volume3
Issue number1
Publication statusPublished - Jan 2006

Fingerprint

Vitamin D
Osteoporosis
Calcium
Therapeutics
Osteomalacia
Bone Matrix
Osteoporotic Fractures
Vitamin D Deficiency
Calcitriol
Sunlight
Intestinal Absorption
Insurance Benefits
Hydroxylation
Skeleton
Autoimmune Diseases
Randomized Controlled Trials
Kidney
Costs and Cost Analysis
Bone and Bones
Skin

Keywords

  • Alfacalcidiol
  • Calcitriol
  • Fracture
  • Osteoporosis
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Gennari, L., Merlotti, D., Martini, G., Valleggi, F., De Paola, V., & Nuti, R. (2006). Vitamin D and its metabolites in the pathogenesis and treatment of osteoporosis. Clinical Cases in Mineral and Bone Metabolism, 3(1), 23-34.

Vitamin D and its metabolites in the pathogenesis and treatment of osteoporosis. / Gennari, Luigi; Merlotti, Daniela; Martini, Giuseppe; Valleggi, Fabrizio; De Paola, Vincenzo; Nuti, Ranuccio.

In: Clinical Cases in Mineral and Bone Metabolism, Vol. 3, No. 1, 01.2006, p. 23-34.

Research output: Contribution to journalArticle

Gennari, L, Merlotti, D, Martini, G, Valleggi, F, De Paola, V & Nuti, R 2006, 'Vitamin D and its metabolites in the pathogenesis and treatment of osteoporosis', Clinical Cases in Mineral and Bone Metabolism, vol. 3, no. 1, pp. 23-34.
Gennari L, Merlotti D, Martini G, Valleggi F, De Paola V, Nuti R. Vitamin D and its metabolites in the pathogenesis and treatment of osteoporosis. Clinical Cases in Mineral and Bone Metabolism. 2006 Jan;3(1):23-34.
Gennari, Luigi ; Merlotti, Daniela ; Martini, Giuseppe ; Valleggi, Fabrizio ; De Paola, Vincenzo ; Nuti, Ranuccio. / Vitamin D and its metabolites in the pathogenesis and treatment of osteoporosis. In: Clinical Cases in Mineral and Bone Metabolism. 2006 ; Vol. 3, No. 1. pp. 23-34.
@article{981d39c01f3d4babba633245bf6714d0,
title = "Vitamin D and its metabolites in the pathogenesis and treatment of osteoporosis",
abstract = "Vitamin D and calcium are essential for normal skeletal growth and for maintaining the mechanical and structural integrity of the skeleton. Reduced intake of calcium and vitamin D may be associated with reduced bone mass and osteoporosis while a chronic and severe vitamin D deficiency may lead to osteomalacia. 1,25(OH)2D (calcitriol) is the major active metabolite of vitamin D and promotes intestinal calcium absorption and the mineralization of bone matrix and reduces PTH secretion. Despite vitamin D and calcium are considered essential components of management strategies for the prevention and treatment of osteoporosis, many people do not have adequate vitamin D levels. Vitamin D insufficiency is particularly common in the elderly due to reduced exposition to sunlight, declined synthesis of vitamin D in the skin and impaired renal hydroxylation. Even though secure inferences from randomized controlled trials on the prevention of osteoporotic fracture with vitamin D or its metabolites are limited, these compounds have been demonstrated to be pharmacologically active, safe and cost-effective for the prevention of age-related bone loss. Their use should be encouraged expecially in elderly subjects or in condition of dietary deficiencies. Interestingly, health benefits of vitamin D and its analogues may go beyond osteoporosis, including prevention of cancer and autoimmune diseases and improvement of neuromuscular function.",
keywords = "Alfacalcidiol, Calcitriol, Fracture, Osteoporosis, Vitamin D",
author = "Luigi Gennari and Daniela Merlotti and Giuseppe Martini and Fabrizio Valleggi and {De Paola}, Vincenzo and Ranuccio Nuti",
year = "2006",
month = "1",
language = "English",
volume = "3",
pages = "23--34",
journal = "Clinical Cases in Mineral and Bone Metabolism",
issn = "1724-8914",
publisher = "CIC Edizioni Internazionali s.r.l.",
number = "1",

}

TY - JOUR

T1 - Vitamin D and its metabolites in the pathogenesis and treatment of osteoporosis

AU - Gennari, Luigi

AU - Merlotti, Daniela

AU - Martini, Giuseppe

AU - Valleggi, Fabrizio

AU - De Paola, Vincenzo

AU - Nuti, Ranuccio

PY - 2006/1

Y1 - 2006/1

N2 - Vitamin D and calcium are essential for normal skeletal growth and for maintaining the mechanical and structural integrity of the skeleton. Reduced intake of calcium and vitamin D may be associated with reduced bone mass and osteoporosis while a chronic and severe vitamin D deficiency may lead to osteomalacia. 1,25(OH)2D (calcitriol) is the major active metabolite of vitamin D and promotes intestinal calcium absorption and the mineralization of bone matrix and reduces PTH secretion. Despite vitamin D and calcium are considered essential components of management strategies for the prevention and treatment of osteoporosis, many people do not have adequate vitamin D levels. Vitamin D insufficiency is particularly common in the elderly due to reduced exposition to sunlight, declined synthesis of vitamin D in the skin and impaired renal hydroxylation. Even though secure inferences from randomized controlled trials on the prevention of osteoporotic fracture with vitamin D or its metabolites are limited, these compounds have been demonstrated to be pharmacologically active, safe and cost-effective for the prevention of age-related bone loss. Their use should be encouraged expecially in elderly subjects or in condition of dietary deficiencies. Interestingly, health benefits of vitamin D and its analogues may go beyond osteoporosis, including prevention of cancer and autoimmune diseases and improvement of neuromuscular function.

AB - Vitamin D and calcium are essential for normal skeletal growth and for maintaining the mechanical and structural integrity of the skeleton. Reduced intake of calcium and vitamin D may be associated with reduced bone mass and osteoporosis while a chronic and severe vitamin D deficiency may lead to osteomalacia. 1,25(OH)2D (calcitriol) is the major active metabolite of vitamin D and promotes intestinal calcium absorption and the mineralization of bone matrix and reduces PTH secretion. Despite vitamin D and calcium are considered essential components of management strategies for the prevention and treatment of osteoporosis, many people do not have adequate vitamin D levels. Vitamin D insufficiency is particularly common in the elderly due to reduced exposition to sunlight, declined synthesis of vitamin D in the skin and impaired renal hydroxylation. Even though secure inferences from randomized controlled trials on the prevention of osteoporotic fracture with vitamin D or its metabolites are limited, these compounds have been demonstrated to be pharmacologically active, safe and cost-effective for the prevention of age-related bone loss. Their use should be encouraged expecially in elderly subjects or in condition of dietary deficiencies. Interestingly, health benefits of vitamin D and its analogues may go beyond osteoporosis, including prevention of cancer and autoimmune diseases and improvement of neuromuscular function.

KW - Alfacalcidiol

KW - Calcitriol

KW - Fracture

KW - Osteoporosis

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=33750940810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750940810&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33750940810

VL - 3

SP - 23

EP - 34

JO - Clinical Cases in Mineral and Bone Metabolism

JF - Clinical Cases in Mineral and Bone Metabolism

SN - 1724-8914

IS - 1

ER -