Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues

Stefano Stagi, Donato Rigante

Research output: Contribution to journalReview articlepeer-review


Systemic lupus erythematosus (SLE) and juvenile SLE (jSLE) are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors. It has been assumed that vitamin D deficiency may have a role in the immune activation of patients with SLE and play an active part in many comorbidities and even complications. A host of clinical studies suggested that vitamin D exerts inhibitory effects on many immunological abnormalities associated with SLE, also in children and adolescents, while different reports have hypothesized that vitamin D may be associated with accelerated cardiovascular disease in SLE. This review updates and summarizes the information related to the immunoregulatory effects of vitamin D and its importance in jSLE, discusses the innumerable correlations between vitamin D and disease activity, including clinical expression and gene polymorphisms of vitamin D receptor as well as the recommendations for vitamin D supplementation in these patients. Despite the excitement raised by many data obtained about vitamin D and its influence on several aspects of the disease, further well-designed perspective trials are required to define the exact role that vitamin D may have in the management of both SLE and jSLE.

Original languageEnglish
Pages (from-to)290-300
Number of pages11
JournalAutoimmunity Reviews
Issue number3
Publication statusPublished - Mar 1 2018


  • Bone density
  • Bone fractures
  • Bone metabolism
  • Juvenile systemic lupus erythemathosus
  • Lupus nephritis
  • Osteoporosis
  • Systemic lupus erythematosus
  • Vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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