Vitamin D and Neurological Diseases: An Endocrine View

Carolina Di Somma, Elisabetta Scarano, Luigi Barrea, Volha V Zhukouskaya, Silvia Savastano, Chiara Mele, Massimo Scacchi, Gianluca Aimaretti, Annamaria Colao, Paolo Marzullo

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Abstract

Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. In parallel, growing evidence has recognized that a multimodal association links vitamin D system to brain development, functions and diseases. With vitamin D deficiency reaching epidemic proportions worldwide, there is now concern that optimal levels of vitamin D in the bloodstream are also necessary to preserve the neurological development and protect the adult brain. The aim of this review is to highlight the relationship between vitamin D and neurological diseases.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 21 2017

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Di Somma, C., Scarano, E., Barrea, L., Zhukouskaya, V. V., Savastano, S., Mele, C., Scacchi, M., Aimaretti, G., Colao, A., & Marzullo, P. (2017). Vitamin D and Neurological Diseases: An Endocrine View. International Journal of Molecular Sciences, 18(11). https://doi.org/10.3390/ijms18112482