Abstract
Vitamin D is a steroid molecule, mainly produced in the skin that regulates the expression of a large number of genes. Several meta-analyses of epidemiological studies support the evidence that low vitamin D serum level, which is highly prevalent worldwide, could be a 'new' risk factor for many chronic diseases including cancer, and for all-cause mortality. A meta-analysis in healthy subjects suggested that current doses of vitamin D supplements could be associated with decrease in total mortality rates. However, these associations are insufficient to establish causality between vitamin D and all-cause mortality. Furthermore, long-term health effects of high doses of vitamin D, that is, prolonged supplementation and association with different baseline vitamin D levels, remain to be investigated. Several trials are ongoing but population-based, placebo-controlled randomized trials with total mortality as the main endpoint should be planned to confirm a real beneficial effect of vitamin D for non-skeletal diseases and to prove causality.
| Original language | English |
|---|---|
| Pages (from-to) | 16-28 |
| Number of pages | 13 |
| Journal | Pigment Cell and Melanoma Research |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2013 |
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Keywords
- 25(OH)D
- Cancer risk
- Overall mortality
- VDR
- Vitamin D
ASJC Scopus subject areas
- Dermatology
- Oncology
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Vitamin D and overall mortality. / Guerrieri-Gonzaga, Aliana; Gandini, Sara.
In: Pigment Cell and Melanoma Research, Vol. 26, No. 1, 01.2013, p. 16-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin D and overall mortality
AU - Guerrieri-Gonzaga, Aliana
AU - Gandini, Sara
PY - 2013/1
Y1 - 2013/1
N2 - Vitamin D is a steroid molecule, mainly produced in the skin that regulates the expression of a large number of genes. Several meta-analyses of epidemiological studies support the evidence that low vitamin D serum level, which is highly prevalent worldwide, could be a 'new' risk factor for many chronic diseases including cancer, and for all-cause mortality. A meta-analysis in healthy subjects suggested that current doses of vitamin D supplements could be associated with decrease in total mortality rates. However, these associations are insufficient to establish causality between vitamin D and all-cause mortality. Furthermore, long-term health effects of high doses of vitamin D, that is, prolonged supplementation and association with different baseline vitamin D levels, remain to be investigated. Several trials are ongoing but population-based, placebo-controlled randomized trials with total mortality as the main endpoint should be planned to confirm a real beneficial effect of vitamin D for non-skeletal diseases and to prove causality.
AB - Vitamin D is a steroid molecule, mainly produced in the skin that regulates the expression of a large number of genes. Several meta-analyses of epidemiological studies support the evidence that low vitamin D serum level, which is highly prevalent worldwide, could be a 'new' risk factor for many chronic diseases including cancer, and for all-cause mortality. A meta-analysis in healthy subjects suggested that current doses of vitamin D supplements could be associated with decrease in total mortality rates. However, these associations are insufficient to establish causality between vitamin D and all-cause mortality. Furthermore, long-term health effects of high doses of vitamin D, that is, prolonged supplementation and association with different baseline vitamin D levels, remain to be investigated. Several trials are ongoing but population-based, placebo-controlled randomized trials with total mortality as the main endpoint should be planned to confirm a real beneficial effect of vitamin D for non-skeletal diseases and to prove causality.
KW - 25(OH)D
KW - Cancer risk
KW - Overall mortality
KW - VDR
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84871451856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871451856&partnerID=8YFLogxK
U2 - 10.1111/pcmr.12036
DO - 10.1111/pcmr.12036
M3 - Article
C2 - 23045997
AN - SCOPUS:84871451856
VL - 26
SP - 16
EP - 28
JO - Pigment Cell and Melanoma Research
JF - Pigment Cell and Melanoma Research
SN - 1755-1471
IS - 1
ER -