Vitamin D and skin cancer

A meta-analysis

Sara Gandini, Sara Raimondi, Patrizia Gnagnarella, Jean Francois Doré, Patrick Maisonneuve, Alessandro Testori

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases. We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively. The SRR for ff versus wild-type became significant with the inclusion of NMSC. The SRR for the studies on CMM were: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively. There is also a slight indication of a role of dietary Vitamin D in CMM development. In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet.

Original languageEnglish
Pages (from-to)634-641
Number of pages8
JournalEuropean Journal of Cancer
Volume45
Issue number4
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Skin Neoplasms
Vitamin D
Meta-Analysis
Calcitriol Receptors
Cutaneous Malignant Melanoma
Diet
Serum

Keywords

  • Melanoma
  • Skin cancer
  • Vitamin D
  • Vitamin D receptor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Vitamin D and skin cancer : A meta-analysis. / Gandini, Sara; Raimondi, Sara; Gnagnarella, Patrizia; Doré, Jean Francois; Maisonneuve, Patrick; Testori, Alessandro.

In: European Journal of Cancer, Vol. 45, No. 4, 03.2009, p. 634-641.

Research output: Contribution to journalArticle

@article{07aedcebb1ac4f178abc989011dda846,
title = "Vitamin D and skin cancer: A meta-analysis",
abstract = "A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases. We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively. The SRR for ff versus wild-type became significant with the inclusion of NMSC. The SRR for the studies on CMM were: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively. There is also a slight indication of a role of dietary Vitamin D in CMM development. In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet.",
keywords = "Melanoma, Skin cancer, Vitamin D, Vitamin D receptor",
author = "Sara Gandini and Sara Raimondi and Patrizia Gnagnarella and Dor{\'e}, {Jean Francois} and Patrick Maisonneuve and Alessandro Testori",
year = "2009",
month = "3",
doi = "10.1016/j.ejca.2008.10.003",
language = "English",
volume = "45",
pages = "634--641",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Ltd",
number = "4",

}

TY - JOUR

T1 - Vitamin D and skin cancer

T2 - A meta-analysis

AU - Gandini, Sara

AU - Raimondi, Sara

AU - Gnagnarella, Patrizia

AU - Doré, Jean Francois

AU - Maisonneuve, Patrick

AU - Testori, Alessandro

PY - 2009/3

Y1 - 2009/3

N2 - A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases. We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively. The SRR for ff versus wild-type became significant with the inclusion of NMSC. The SRR for the studies on CMM were: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively. There is also a slight indication of a role of dietary Vitamin D in CMM development. In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet.

AB - A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases. We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively. The SRR for ff versus wild-type became significant with the inclusion of NMSC. The SRR for the studies on CMM were: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively. There is also a slight indication of a role of dietary Vitamin D in CMM development. In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet.

KW - Melanoma

KW - Skin cancer

KW - Vitamin D

KW - Vitamin D receptor

UR - http://www.scopus.com/inward/record.url?scp=60149103623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60149103623&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2008.10.003

DO - 10.1016/j.ejca.2008.10.003

M3 - Article

VL - 45

SP - 634

EP - 641

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 4

ER -