Vitamin D and systemic lupus erythematosus: Myth or reality?

Abdulla Watad, Shana G. Neumann, Alessandra Soriano, Howard Amital, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review


There is growing interest in the contribution of vitamin D deficiency to autoimmunity. Several studies have shown an association between low levels of vitamin D and autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, type 1 diabetes, autoimmune thyroid diseases, celiac disease, and systemic lupus erythematosus (SLE). Vitamin D receptor ligands can mediate immunosuppressive effects. It has been suggested that low levels of this hormone contribute to the immune activation in lupus and other autoimmune diseases. This review updates and summarizes the literature on the association between vitamin D and SLE, and discusses the various correlations between vitamin D and SLE activity, clinical expressions, serology, and gene polymorphisms of vitamin D receptors.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalIsrael Medical Association Journal
Issue number3-4
Publication statusPublished - Mar 1 2016
Externally publishedYes


  • Autoimmune disease
  • Autoimmunity
  • Gene polymorphism
  • Immunomodulation
  • Systemic lupus erythematosus (SLE)
  • Vitamin D

ASJC Scopus subject areas

  • Medicine(all)


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