Vitamin D as a biomarker of ill health among the over-50s: A systematic review of cohort studies

Silvia Caristia, Nicoletta Filigheddu, Francesco Barone-Adesi, Andrea Sarro, Tommaso Testa, Corrado Magnani, Gianluca Aimaretti, Fabrizio Faggiano, Paolo Marzullo

Research output: Contribution to journalReview article

Abstract

Background: The association between circulating levels of vitamin D and the incidence of chronic diseases is known. The identification of vitamin D as a biomarker of physiological/pathological ageing could contribute to expanding current knowledge of its involvement in healthy ageing. Methods: According to PRISMA guidelines, a systematic review was conducted on cohorts studying the role of 25OH-Vitamin D [25(OH)D] and 1,25(OH)2-Vitamin D [1,25(OH)2D] concentrations as biomarkers of healthy ageing. We consulted MedLine, Scopus, and Web of Science to search for studies on the association between vitamin D status in populations of originally healthy adults, and outcomes of longevity, illness, and physical and cognitive functionality. The quality of the studies was assessed using the Newcastle Ottawa scale. Results: Twenty cohorts from 24 articles were selected for this review. Inverse associations were found between low 25(OH)D levels and all-cause mortality, respiratory and cardiovascular events, as well as markers relating to hip and non-vertebral fractures. Associations between 1,25(OH)2D and healthy ageing outcomes gave similar results, although of lower clinical significance. Conclusions: This systematic review pinpoints peculiar aspects of vitamin D as a multidimensional predictor of ill health in the ageing process. Further well-designed controlled trials to investigate whether vitamin D supplement results in superior outcomes are warranted in the future.

Original languageEnglish
Article number2384
JournalNutrients
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2019

Fingerprint

systematic review
vitamin D
cohort studies
Vitamin D
biomarkers
Cohort Studies
Biomarkers
Health
ergocalciferol
Ergocalciferols
hips
chronic diseases
Hip
Chronic Disease
Guidelines
incidence
Mortality
Incidence
Population

Keywords

  • Cohorts
  • Healthy ageing
  • Vitamin D

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Caristia, S., Filigheddu, N., Barone-Adesi, F., Sarro, A., Testa, T., Magnani, C., ... Marzullo, P. (2019). Vitamin D as a biomarker of ill health among the over-50s: A systematic review of cohort studies. Nutrients, 11(10), [2384]. https://doi.org/10.3390/nu11102384

Vitamin D as a biomarker of ill health among the over-50s : A systematic review of cohort studies. / Caristia, Silvia; Filigheddu, Nicoletta; Barone-Adesi, Francesco; Sarro, Andrea; Testa, Tommaso; Magnani, Corrado; Aimaretti, Gianluca; Faggiano, Fabrizio; Marzullo, Paolo.

In: Nutrients, Vol. 11, No. 10, 2384, 10.2019.

Research output: Contribution to journalReview article

Caristia, S, Filigheddu, N, Barone-Adesi, F, Sarro, A, Testa, T, Magnani, C, Aimaretti, G, Faggiano, F & Marzullo, P 2019, 'Vitamin D as a biomarker of ill health among the over-50s: A systematic review of cohort studies', Nutrients, vol. 11, no. 10, 2384. https://doi.org/10.3390/nu11102384
Caristia S, Filigheddu N, Barone-Adesi F, Sarro A, Testa T, Magnani C et al. Vitamin D as a biomarker of ill health among the over-50s: A systematic review of cohort studies. Nutrients. 2019 Oct;11(10). 2384. https://doi.org/10.3390/nu11102384
Caristia, Silvia ; Filigheddu, Nicoletta ; Barone-Adesi, Francesco ; Sarro, Andrea ; Testa, Tommaso ; Magnani, Corrado ; Aimaretti, Gianluca ; Faggiano, Fabrizio ; Marzullo, Paolo. / Vitamin D as a biomarker of ill health among the over-50s : A systematic review of cohort studies. In: Nutrients. 2019 ; Vol. 11, No. 10.
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