Vitamin D-binding protein and multiple sclerosis

Evidence, controversies, and needs

Research output: Contribution to journalReview article

Abstract

The vitamin D-binding protein (DBP) occupies a key node in the regulation of the vitamin D system. Being the main plasma carrier of vitamin D metabolites, it regulates their stability and bioavailability. However, DBP is also a multifunctional protein with roles in the organism’s actin scavenging system and immunomodulation. All these activities may affect multiple sclerosis (MS) pathophysiology. DBP can be measured in blood and cerebrospinal fluid, body fluids that have been investigated as sources of accessible biomarkers of MS. Yet, available data on DBP expression and function in MS are scattered and somewhat controversial. Aims of this review are to summarize current evidence from studies on DBP in MS patients, to discuss possible shortcomings and to highlight key points that need to be addressed to gain deeper insight into the role of DBP in MS.

Original languageEnglish
Pages (from-to)1526-1535
Number of pages10
JournalMultiple Sclerosis Journal
Volume24
Issue number12
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Vitamin D-Binding Protein
Multiple Sclerosis
Carrier Proteins
Vitamin D
Immunomodulation
Body Fluids
Biological Availability
Cerebrospinal Fluid
Actins
Biomarkers
Proteins

Keywords

  • vitamin D-binding prote
  • Multiple Sclerosis (MS)
  • vitamin D status

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Vitamin D-binding protein and multiple sclerosis : Evidence, controversies, and needs. / Gauzzi, Maria Cristina.

In: Multiple Sclerosis Journal, Vol. 24, No. 12, 01.10.2018, p. 1526-1535.

Research output: Contribution to journalReview article

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