Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort

Cristina Agliardi; Franca Rosa Guerini; Milena Zanzottera; Elisabetta Bolognesi; Andrea Saul Costa; Mario Clerici

doi:10.1016/j.jneuroim.2017.02.009

Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort

Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Andrea Saul Costa, Mario Clerici

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Vitamin D binding protein (DBP) gene encodes for Gc, an α₂ globulin that transports vitamin D metabolites in serum. Given the role of vitamin D in MS onset and disease progression we analyzed the frequencies of three polymorphisms (rs7041, rs4588 and rs2282679) within DBP gene in 701 Italian multiple sclerosis (MS) patients and 831 healthy controls (HC). None of the polymorphisms showed any association with MS onset and progression. Our results suggest that DBP is not involved in the pathogenesis of MS in Italians.

Original language	English
Pages (from-to)	92-95
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	305
DOIs	https://doi.org/10.1016/j.jneuroim.2017.02.009
Publication status	Published - Apr 15 2017

Keywords

DBP
Gc
Multiple sclerosis
Polymorphism
SNP
Vitamin D

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2017.02.009

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title = "Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort",

abstract = "Vitamin D binding protein (DBP) gene encodes for Gc, an α2 globulin that transports vitamin D metabolites in serum. Given the role of vitamin D in MS onset and disease progression we analyzed the frequencies of three polymorphisms (rs7041, rs4588 and rs2282679) within DBP gene in 701 Italian multiple sclerosis (MS) patients and 831 healthy controls (HC). None of the polymorphisms showed any association with MS onset and progression. Our results suggest that DBP is not involved in the pathogenesis of MS in Italians.",

keywords = "DBP, Gc, Multiple sclerosis, Polymorphism, SNP, Vitamin D",

author = "Cristina Agliardi and Guerini, {Franca Rosa} and Milena Zanzottera and Elisabetta Bolognesi and Costa, {Andrea Saul} and Mario Clerici",

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T1 - Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort

AU - Agliardi, Cristina

AU - Guerini, Franca Rosa

AU - Zanzottera, Milena

AU - Bolognesi, Elisabetta

AU - Costa, Andrea Saul

AU - Clerici, Mario

PY - 2017/4/15

Y1 - 2017/4/15

N2 - Vitamin D binding protein (DBP) gene encodes for Gc, an α2 globulin that transports vitamin D metabolites in serum. Given the role of vitamin D in MS onset and disease progression we analyzed the frequencies of three polymorphisms (rs7041, rs4588 and rs2282679) within DBP gene in 701 Italian multiple sclerosis (MS) patients and 831 healthy controls (HC). None of the polymorphisms showed any association with MS onset and progression. Our results suggest that DBP is not involved in the pathogenesis of MS in Italians.

AB - Vitamin D binding protein (DBP) gene encodes for Gc, an α2 globulin that transports vitamin D metabolites in serum. Given the role of vitamin D in MS onset and disease progression we analyzed the frequencies of three polymorphisms (rs7041, rs4588 and rs2282679) within DBP gene in 701 Italian multiple sclerosis (MS) patients and 831 healthy controls (HC). None of the polymorphisms showed any association with MS onset and progression. Our results suggest that DBP is not involved in the pathogenesis of MS in Italians.

KW - DBP

KW - Gc

KW - Multiple sclerosis

KW - Polymorphism

KW - SNP

KW - Vitamin D

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M3 - Article

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -

Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort

Abstract

Keywords

ASJC Scopus subject areas

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