Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort

Research output: Contribution to journalArticle

Abstract

Vitamin D binding protein (DBP) gene encodes for Gc, an α2 globulin that transports vitamin D metabolites in serum. Given the role of vitamin D in MS onset and disease progression we analyzed the frequencies of three polymorphisms (rs7041, rs4588 and rs2282679) within DBP gene in 701 Italian multiple sclerosis (MS) patients and 831 healthy controls (HC). None of the polymorphisms showed any association with MS onset and progression. Our results suggest that DBP is not involved in the pathogenesis of MS in Italians.

Original languageEnglish
Pages (from-to)92-95
Number of pages4
JournalJournal of Neuroimmunology
Volume305
DOIs
Publication statusPublished - Apr 15 2017

Keywords

  • DBP
  • Gc
  • Multiple sclerosis
  • Polymorphism
  • SNP
  • Vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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