We studied 43 children, whose ages ranged from 2 yr and 3 mth to 15 yr, with normal renal function, total protein urinary excretion greater than 40 mg/m 2/hr, serum proteins 3, creatinine. 24-hr urinary collections were obtained for the measurement of total proteins, albumin, transferrin, IgG, Gc-protein, creatinine. The total protein content of the 24-hr urinary collections was determined by the biuret method; albumin, transferrin, IgG, Gc-protein were determined by radioimmunodiffusion; 25(OH)-vitamin by radioimmunoassay. Plasma concentration of Gc protein was significantly reduced in group-A patients, while it was still normal in group-B. The urinary excretion of vitamin-D binding protein was similar in the two groups of patients, both in absolute terms (mg/m 2/day) and in relation to protein excretion (mg/g protein). The blood level of proteins, albumin, 25(OH)-vitamin OH Vitamin-D 3 and the degree of proteinuria were similar in the two groups. It was possible to show a direct significant relation between serum proteins and serum Gc-protein, and between serum albumin and serum Gc-protein in both groups. In addition in group-A there was a significant direct relation between plasma 25(OH)-vitamin and plasma Gc-protein. The conclusions are: (a) Gc-protein is constantly lost during the course of nephrotic syndrome whatever the histology, (b) the diagnostic value of Gc-protein for the evaluation of the metabolism of vitamin D is limited.
|Translated title of the contribution||Vitamin D binding protein in childhood nephrotic syndrome|
|Number of pages||6|
|Journal||Rivista Italiana di Pediatria|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health