Vitamin D binding protein in endometriosis

Simone Ferrero, David J. Gillott, Paola Anserini, Valentino Remorgida, Karen M. Price, Nicola Ragni, Jurgis G. Grudzinskas

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Two-dimensional gel electrophoresis is a powerful method for identifying post-translationally modified molecules in biological fluids. We examined the presence and expression of vitamin D binding protein (DBP) in the peritoneal fluid (PF) and plasma (PL) of women with endometriosis. METHODS: PL and PF samples were obtained from 36 women with untreated mild endometriosis (revised classification of the American Fertility Society [rAFS] stage I-II), 52 women with untreated severe endometriosis (rAFS stage III-IV), 17 women with endometriosis treated with the oral contraceptive (OC), and 40 controls (infertility, n = 23; tubal sterilization, n = 12; pelvic pain, n = 5). PF and PL samples were analyzed by quantitative, high-resolution 2-dimensional gel electrophoresis. RESULTS: The expression of one DBP isoform (DBPE) in the PF of patients with untreated endometriosis was significantly lower than in the control group (P

Original languageEnglish
Pages (from-to)272-277
Number of pages6
JournalJournal of the Society for Gynecologic Investigation
Volume12
Issue number4
DOIs
Publication statusPublished - May 2005

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Keywords

  • Endometriosis
  • Peritoneal fluid
  • Two-dimensional gel electrophoresis
  • Vitamin D binding protein

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Ferrero, S., Gillott, D. J., Anserini, P., Remorgida, V., Price, K. M., Ragni, N., & Grudzinskas, J. G. (2005). Vitamin D binding protein in endometriosis. Journal of the Society for Gynecologic Investigation, 12(4), 272-277. https://doi.org/10.1016/j.jsgi.2005.01.027