Vitamine D, cardio-inflammation, et dysfonction endothéliale chez les personnes âgées après chirurgie orthopédique: résultats d'un étude clinique ouvert pour améliorer la fonction cardiaque

Translated title of the contribution: Vitamin D, cardio-inflammation, and endothelial dysfunction in older adults after orthopedic surgery: Results from an open-label trial to ameliorate cardiac function

Matteo Briguglio, Giovanni Lombardi, Veronica Sansoni, Silvia Perego, Vito De Gennaro Colonna, Daniele Stella, Chiara Colombo, Marika Bonadies, Giuseppe De Blasio, Giuseppe Banfi, Maurizio Turiel

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: After orthopedic surgery, clinical outcomes are affected by comorbid cardiovascular diseases (CVDs) and low 25-hydroxy-vitamin D (25-(OH)D). Myocardial function was suggested to be influenced by both the pro-inflammatory cytokine tumour necrosis factor alpha (TNFα) and the marker of endothelial dysfunction asymmetric dimethylarginine (ADMA). Material and methods: We investigated TNFα and ADMA changes in association with serum levels of vitamin D and cardiac function in 47 older adults after major orthopedic surgery. Subjects were characterized for biochemical profiles and transthoracic echocardiographic measures. Assessments were done before and after the correction of hypovitaminosis D through a 6-month supplementation with calcifediol started at post-operative rehabilitation. Results: The means serum levels of both TNFα and ADMA reduced from 1.39 ± 0.47 pg/mL to 1.30 ± 0.37 pg/mL (P < 0.05) and from 0.69 ± 0.05 μmol/L to 0.68 ± 0.04 μmol/L (P < 0.05), respectively. Significant treatment effects were observed for systolic blood pressure (P < 0.05), left ventricular ejection function (P < 0.01), global longitudinal strain (P < 0.0001), 25-(OH)D (P < 0.001), and calcemia (P < 0.001). Conclusion: After the normalization of low levels of vitamin D, we were able to observe a reduction of circulating TNFα and ADMA together with the amelioration of cardiac function. Even if our results suggest that vitamin D might exert cardiac effects indirectly through the decrease in cardio-inflammation and endothelial dysfunction, a better understanding of the precise molecular regulations should be better investigated.

Translated title of the contributionVitamin D, cardio-inflammation, and endothelial dysfunction in older adults after orthopedic surgery: Results from an open-label trial to ameliorate cardiac function
Original languageFrench
Pages (from-to)313-318
Number of pages6
JournalNutrition Clinique et Metabolisme
Volume34
Issue number4
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Asymmetric dimethylarginine
  • Global longitudinal strain
  • Left ventricular ejection fraction
  • Tumor necrosis factor-alpha
  • Vitamin D

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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