Vitamin D deficiency and clinical outcome in patients with chronic heart failure: A review

C. D'Amore, F. Marsico, A. Parente, S. Paolillo, F. De Martino, P. Gargiulo, F. Ferrazzano, A. M. De Roberto, L. La Mura, C. Marciano, S. Dellegrottaglie, B. Trimarco, P. Perrone Filardi

Research output: Contribution to journalReview articlepeer-review


Aim The aim of this review was to summarize evidence on the role of Vitamin D deficiency in heart failure (HF), from pathophysiological mechanisms to clinical effects of Vitamin D supplementation. Data synthesis Chronic HF secondary to left ventricular (LV) systolic dysfunction is a growing health problem, still associated with poor clinical outcome. In recent years, experimental and epidemiological evidence focused on the role of Vitamin D in HF. Cross sectional studies demonstrated that prevalence of HF is increased in patients with Vitamin D deficiency or parathyroid hormone (PTH) plasma level increase, whereas longitudinal studies showed enhanced risk of developing new HF in patients with Vitamin D deficiency. In addition, in patients with established HF, low plasma levels of Vitamin D are associated with worsening clinical outcome. Yet, clinical studies did not definitively demonstrate a benefit of Vitamin D supplementation for preventing HF or ameliorating clinical outcome in patients with established HF. Conclusions Despite convincing experimental and epidemiological data, treatment with Vitamin D supplementation did not show clear evidence of benefit for preventing HF or influencing its clinical course. Ongoing clinical studies will hopefully shed lights on the effects of Vitamin D supplementation on clinical endpoints along the spectrum of HF.

Original languageEnglish
Pages (from-to)837-849
Number of pages13
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number10
Publication statusPublished - Oct 1 2017


  • Cardiovascular outcomes
  • Heart failure
  • Vitamin D deficiency
  • Vitamin D supplementation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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