Vitamin D deficiency and infertility: Insights from in vitro fertilization cycles

Alessio Paffoni; Stefania Ferrari; Paola Viganò; Luca Pagliardini; Enrico Papaleo; Massimo Candiani; Amedea Tirelli; Luigi Fedele; Edgardo Somigliana

doi:10.1210/jc.2014-1802

Vitamin D deficiency and infertility: Insights from in vitro fertilization cycles

Alessio Paffoni, Stefania Ferrari, Paola Viganò, Luca Pagliardini, Enrico Papaleo, Massimo Candiani, Amedea Tirelli, Luigi Fedele, Edgardo Somigliana

Research output: Contribution to journal › Article › peer-review

Abstract

Context: Vitamin D deficiency has been proven to affect fertility in mammals, but data in human is less convincing. In particular, data on in vitro fertilization (IVF), an attractive model to draw information on this topic, are sparse and conflicting.

Objective: Our objective was to investigate IVF outcome in women with deficient 25-hydroxyvitamin D [25 (OH)D] serum levels (

Results: The number of recruited women with serum 25 (OH)D30 ng/mL) had the highest chances of pregnancy.

Conclusions: VitaminDis an emerging factor influencing female fertility and IVF outcome. Additional studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation.

Original language	English
Pages (from-to)	E2372-E2376
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	99
Issue number	11
DOIs	https://doi.org/10.1210/jc.2014-1802
Publication status	Published - Nov 1 2014

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Endocrinology
Biochemistry, medical
Endocrinology, Diabetes and Metabolism
Medicine(all)

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abstract = "Context: Vitamin D deficiency has been proven to affect fertility in mammals, but data in human is less convincing. In particular, data on in vitro fertilization (IVF), an attractive model to draw information on this topic, are sparse and conflicting.Objective: Our objective was to investigate IVF outcome in women with deficient 25-hydroxyvitamin D [25 (OH)D] serum levels (Results: The number of recruited women with serum 25 (OH)D30 ng/mL) had the highest chances of pregnancy.Conclusions: VitaminDis an emerging factor influencing female fertility and IVF outcome. Additional studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation.",

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AU - Paffoni, Alessio

AU - Ferrari, Stefania

AU - Viganò, Paola

AU - Pagliardini, Luca

AU - Papaleo, Enrico

AU - Candiani, Massimo

AU - Tirelli, Amedea

AU - Fedele, Luigi

AU - Somigliana, Edgardo

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AB - Context: Vitamin D deficiency has been proven to affect fertility in mammals, but data in human is less convincing. In particular, data on in vitro fertilization (IVF), an attractive model to draw information on this topic, are sparse and conflicting.Objective: Our objective was to investigate IVF outcome in women with deficient 25-hydroxyvitamin D [25 (OH)D] serum levels (Results: The number of recruited women with serum 25 (OH)D30 ng/mL) had the highest chances of pregnancy.Conclusions: VitaminDis an emerging factor influencing female fertility and IVF outcome. Additional studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation.

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Vitamin D deficiency and infertility: Insights from in vitro fertilization cycles

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