Vitamin D deficiency and infertility: Insights from in vitro fertilization cycles

Alessio Paffoni, Stefania Ferrari, Paola Viganò, Luca Pagliardini, Enrico Papaleo, Massimo Candiani, Amedea Tirelli, Luigi Fedele, Edgardo Somigliana

Research output: Contribution to journalArticlepeer-review


Context: Vitamin D deficiency has been proven to affect fertility in mammals, but data in human is less convincing. In particular, data on in vitro fertilization (IVF), an attractive model to draw information on this topic, are sparse and conflicting.

Objective: Our objective was to investigate IVF outcome in women with deficient 25-hydroxyvitamin D [25 (OH)D] serum levels (

Results: The number of recruited women with serum 25 (OH)D30 ng/mL) had the highest chances of pregnancy.

Conclusions: VitaminDis an emerging factor influencing female fertility and IVF outcome. Additional studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation.

Original languageEnglish
Pages (from-to)E2372-E2376
JournalJournal of Clinical Endocrinology and Metabolism
Issue number11
Publication statusPublished - Nov 1 2014

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)


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