Vitamin D deficiency and primary hyperparathyroidism.

R. Nuti, D. Merlotti, L. Gennari

Research output: Contribution to journalArticle

Abstract

Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation. While the effects of vitamin D depletion in the pathogenesis of secondary hyperparathyroidism in elderly individuals or in the occurrence of parathyroid hyperplasia in patients with renal insufficiency are well established, the association between hypovitaminosis D and primary hyperparathyroidism (P-HPT) has only recently become appreciated. In different cohorts of patients with P-HPT, vitamin D deficiency has been recently associated with higher PTH levels, larger adenomas, and a more severe phenotype (including osteitis fibrosa cystica) as well as negative post-operative outcomes following parathyroidectomy. Despite current guidelines recommend measurement of serum 25OHD (25-hydroxy-cholecalciferol) in P-HPT and their repletion if the levels are

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalJournal of Endocrinological Investigation
Volume34
Issue number7 Suppl
Publication statusPublished - Jul 2011

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Vitamin D Deficiency
Primary Hyperparathyroidism
Vitamin D
Osteitis Fibrosa Cystica
Parathyroidectomy
Secondary Hyperparathyroidism
Cholecalciferol
Adenoma
Hyperplasia
Renal Insufficiency
Cell Proliferation
Guidelines
Phenotype
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Nuti, R., Merlotti, D., & Gennari, L. (2011). Vitamin D deficiency and primary hyperparathyroidism. Journal of Endocrinological Investigation, 34(7 Suppl), 45-49.

Vitamin D deficiency and primary hyperparathyroidism. / Nuti, R.; Merlotti, D.; Gennari, L.

In: Journal of Endocrinological Investigation, Vol. 34, No. 7 Suppl, 07.2011, p. 45-49.

Research output: Contribution to journalArticle

Nuti, R, Merlotti, D & Gennari, L 2011, 'Vitamin D deficiency and primary hyperparathyroidism.', Journal of Endocrinological Investigation, vol. 34, no. 7 Suppl, pp. 45-49.
Nuti, R. ; Merlotti, D. ; Gennari, L. / Vitamin D deficiency and primary hyperparathyroidism. In: Journal of Endocrinological Investigation. 2011 ; Vol. 34, No. 7 Suppl. pp. 45-49.
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