Vitamin D Homeostasis and Diseases in Pediatrics

Research output: Contribution to journalArticle

Abstract

Vitamin D is essential for growth and development, starting with intrauterine life. It is the key factor for intestinal calcium absorption and, consequently, for bone formation and turnover. It has been known for a long time that, in children, lack of Vitamin D leads to rickets. Recent investigations have explored the many physiological roles of Vitamin D on different organs and systems, and the problems of Vitamin D insufficiency or deficiency in both health and disease. We now know that many otherwise healthy and well-nourished children have low Vitamin D reserves and sub-optimal bone development, even in developed countries, and that these problems are compounded in children affected by a wide variety of chronic diseases, from cystic fibrosis to Duchenne muscular dystrophy. Vitamin D supplementation is now recommended in many countries, and some countries even encourage commercial food enrichment with Vitamin D (e.g., "fortified" milk). Medically prescribed treatment with Vitamin D or its active metabolites is also becoming a standard-of-care in the management of several chronic diseases and conditions.

Original languageEnglish
Pages (from-to)189-201
Number of pages13
JournalFrontiers of Hormone Research
Volume50
DOIs
Publication statusPublished - Jan 1 2018

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Vitamin D
Homeostasis
Pediatrics
Chronic Disease
Avitaminosis
Rickets
Duchenne Muscular Dystrophy
Bone Remodeling
Bone Development
Intestinal Absorption
Standard of Care
Growth and Development
Developed Countries
Osteogenesis
Cystic Fibrosis
Milk
Calcium
Food
Health

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Vitamin D Homeostasis and Diseases in Pediatrics. / Bianchi, Maria Luisa.

In: Frontiers of Hormone Research, Vol. 50, 01.01.2018, p. 189-201.

Research output: Contribution to journalArticle

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