Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease

Nancy Agmon-Levin, Ron Kopilov, Carlo Selmi, Udi Nussinovitch, María Sánchez-Castañón, Marcos López-Hoyos, Howie Amital, Shaye Kivity, Eric M. Gershwin, Yehuda Shoenfeld

Research output: Contribution to journalArticle

Abstract

Vitamin D immune-modulating effects were extensively studied, and low levels have been linked with autoimmune diseases. The associations of vitamin D with autoimmune diseases of the liver, and particularly primary biliary cirrhosis (PBC), are yet to be defined. Hence, in this study, serum levels of vitamin D were determined in 79 patients with PBC and 70 age- and sex-matched controls by the LIAISON chemiluminescent immunoassays (DiaSorin—Italy). Clinical and serological parameters of patients were analyzed with respect to vitamin D status. Mean levels of vitamin D were significantly lower among patients with PBC compared with controls (16.8 ± 9 vs. 22.1 ± 9 ng/ml; p = 0.029), and vitamin D deficiency (≤10 ng/ml) was documented in 33 % of patients with PBC versus 7 % of controls (p 

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalImmunologic Research
Volume61
Issue number1-2
DOIs
Publication statusPublished - 2014

Keywords

  • Autoantibodies
  • Autoimmunity
  • Liver
  • PBC (primary biliary cirrhosis)
  • Vitamin D

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

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    Agmon-Levin, N., Kopilov, R., Selmi, C., Nussinovitch, U., Sánchez-Castañón, M., López-Hoyos, M., Amital, H., Kivity, S., Gershwin, E. M., & Shoenfeld, Y. (2014). Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease. Immunologic Research, 61(1-2), 141-146. https://doi.org/10.1007/s12026-014-8594-0