Vitamin D in trichology: a comprehensive review of the role of Vitamin D and its receptor in hair and scalp disorders

Giovanni Damiani, Rosalynn Conic, Gloria Orlando, Anna Zampetti, Elena Marinello, Manuela Piai, Michael D Linder

Research output: Contribution to journalArticlepeer-review

Abstract

Vitamin D plays an important role in maintaining the homeostasis of various biological systems. Besides its well known function in calcium and phosphate metabolism, it plays a major role in pathophysiology of skin and adnexa. Indeed, Vitamin D, through its receptor (VDR), decreases keratinocyte proliferation, improve their differentiation and modulate both cutaneous innate (antimicrobial activity and antigen presentation)and adaptative immunity (T and B lymphocyte function). The mainteintenance of normal hair is dependent on the integrity of the dermis, epidermis and hair cycles. Besides its effect on epidermal differentiation, VDR plays a vital role in preserving the hair follicle integrity. While the relevance of VDR has been fully elucidated, the real value of Vitamin D in the hair follicle cycle still remains uncertain. To date, results in literature remain contradicting and far from definitive; still, the role of vitamin D in the various forms humans alopecia is likely to be significant. The aim of this article is to review evidence about the role of Vitamin D and its receptor in trichology, with a focus on scarring and non-scarring alopecias and in particular on the potential therapeutic use of Vitamin D for hair and scalp disorders.

Original languageEnglish
JournalGiornale Italiano di Dermatologia e Venereologia
DOIs
Publication statusE-pub ahead of print - Jun 17 2019
Externally publishedYes

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