Vitamin D insufficiency in obese children and relation with lipid profile

Roberto Ercole Rusconi, Valentina De Cosmi, Ghilardi Gianluca, Claudia Giavoli, Carlo Agostoni

Research output: Contribution to journalArticle

Abstract

Vitamin D (25OHD) deficiency is reported in obese children. Low 25OHD levels are associated with dyslipidemia and increased risk of cardiovascular complication in adulthood. Within an observational study, 120 obese subjects in pediatric age were enrolled: 59 had 25OHD 20ng/ml (group B). Group A versus Group B showed elevated total cholesterol (TC), p=0.017, low-density lipoprotein cholesterol (LDL-C), p=0.045, and parathormone (PTH), p=0.008. Apolipoprotein B (ApoB) showed a similar trend, p=0.074. Negative correlations were found between 25OHD and the following parameters: TC (ρ=-0.22, p=0.01), LDL (ρ=-0.22; p=0.03), ApoB (ρ=-0.20; p=0.03), and PTH (ρ=-0.33, p=0.003). No differences in High Lipoprotein Cholesterol (HDL-C) were found. In multivariate regression the most powerful predictor for explaining 25OHD variation were TC (p=0.048) and PTH (p=0.055). Within a pediatric obese population an association between 25OHD low levels and unfavourable lipid patterns has been found.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalInternational Journal of Food Sciences and Nutrition
Volume66
Issue number2
DOIs
Publication statusPublished - Mar 1 2015

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Keywords

  • Cardiovascular risk
  • Lipoproteins
  • Obesity
  • Vitamin D

ASJC Scopus subject areas

  • Food Science
  • Medicine(all)

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