Vitamin D insufficiency predicts time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL)

Stefano Molica, Giovanna Digiesi, Anna Antenucci, Luciano Levato, Rosanna Mirabelli, Matteo Molica, Massimo Gentile, Diana Giannarelli, Isabella Sperduti, Fortunato Morabito, Laura Conti

Research output: Contribution to journalArticlepeer-review

Abstract

Although vitamin D insufficiency is related to inferior prognosis in some cancers, limited data exist in hematologic malignancies. We evaluated the relationship between 25(OH)D serum levels and time to first treatment (TFT), a disease-specific end point, in 130 previously untreated Binet stage A chronic lymphocytic leukemia (CLL) patients. Measurement of 25(OH)D was performed by means of a direct, competitive chemiluminescence immunoassay using the DiaSorin LIAISON 25(OH)D TOTAL assay (DiaSorin, Inc., Stillwater, Minnesota). Overall, 41 patients (31.5%) had severe vitamin D insufficiency (

Original languageEnglish
Pages (from-to)443-447
Number of pages5
JournalLeukemia Research
Volume36
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Clinical outcome
  • CLL
  • Prognostic variables
  • Vitamin D

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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