Vitamin D insufficiency predicts time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL)

Stefano Molica; Giovanna Digiesi; Anna Antenucci; Luciano Levato; Rosanna Mirabelli; Matteo Molica; Massimo Gentile; Diana Giannarelli; Isabella Sperduti; Fortunato Morabito; Laura Conti

doi:10.1016/j.leukres.2011.10.004

Vitamin D insufficiency predicts time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL)

Stefano Molica, Giovanna Digiesi, Anna Antenucci, Luciano Levato, Rosanna Mirabelli, Matteo Molica, Massimo Gentile, Diana Giannarelli, Isabella Sperduti, Fortunato Morabito, Laura Conti

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

Although vitamin D insufficiency is related to inferior prognosis in some cancers, limited data exist in hematologic malignancies. We evaluated the relationship between 25(OH)D serum levels and time to first treatment (TFT), a disease-specific end point, in 130 previously untreated Binet stage A chronic lymphocytic leukemia (CLL) patients. Measurement of 25(OH)D was performed by means of a direct, competitive chemiluminescence immunoassay using the DiaSorin LIAISON 25(OH)D TOTAL assay (DiaSorin, Inc., Stillwater, Minnesota). Overall, 41 patients (31.5%) had severe vitamin D insufficiency (

Original language	English
Pages (from-to)	443-447
Number of pages	5
Journal	Leukemia Research
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.leukres.2011.10.004
Publication status	Published - Apr 2012

Keywords

Clinical outcome
CLL
Prognostic variables
Vitamin D

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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Vitamin D insufficiency predicts time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL). / Molica, Stefano; Digiesi, Giovanna; Antenucci, Anna; Levato, Luciano; Mirabelli, Rosanna; Molica, Matteo; Gentile, Massimo; Giannarelli, Diana ; Sperduti, Isabella; Morabito, Fortunato; Conti, Laura.

In: Leukemia Research, Vol. 36, No. 4, 04.2012, p. 443-447.

Research output: Contribution to journal › Article › peer-review

Molica, Stefano ; Digiesi, Giovanna ; Antenucci, Anna ; Levato, Luciano ; Mirabelli, Rosanna ; Molica, Matteo ; Gentile, Massimo ; Giannarelli, Diana ; Sperduti, Isabella ; Morabito, Fortunato ; Conti, Laura. / Vitamin D insufficiency predicts time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL). In: Leukemia Research. 2012 ; Vol. 36, No. 4. pp. 443-447.

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AU - Antenucci, Anna

AU - Levato, Luciano

AU - Mirabelli, Rosanna

AU - Molica, Matteo

AU - Gentile, Massimo

AU - Giannarelli, Diana

AU - Sperduti, Isabella

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AU - Conti, Laura

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