Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis

Research output: Contribution to journalArticlepeer-review

Abstract

Vitamin D is a key molecule in calcium and phosphate homeostasis; however, increasing evidence has recently shown that it also plays a crucial role in the immune system, both innate and adaptive. A deregulation of vitamin D levels, due also to mutations and polymorphisms in the genes of the vitamin D pathway, determines severe alterations in the homeostasis of the organism, resulting in a higher risk of onset of some diseases, including osteoporosis. This review gives an overview of the influence of vitamin D levels on the pathogenesis of osteoporosis, between bone homeostasis and immune system.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalCurrent Osteoporosis Reports
DOIs
Publication statusAccepted/In press - 2017

Keywords

  • Calcium-phosphorus homeostasis
  • Immune system
  • Osteoporosis
  • Polymorphisms
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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