Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

Valerio Nobili, Valentina Giorgio, Daniela Liccardo, Giorgio Bedogni, Giuseppe Morino, Anna Alisi, Stefano Cianfarani

Research output: Contribution to journalArticlepeer-review


Objective: To investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD). Subjects and methods: In this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with persistently elevated serum aminotransferase levels and diffusely hyperechogenic liver on ultrasonography were selected for liver biopsy. Nonalcoholic steatohepatitis (NASH) and fibrosis were histologically diagnosed using NAFLD Clinical Research Network (CRN) criteria. The plasma levels of 25-OH-VD were measured by HPLC. Bone mineral density (BMD) of lumbar spine was evaluated by dual-energy X-ray absorptiometry. Multiple linear regression analysis was used to evaluate the association between 25-OH-VD levels and the predictors of interest after correction for age, gender, waist circumference, BMI, and other potential confounders. Results: The children (64% males) were aged 8-18 years, and their median BMI was 2.45 SDS. Both parathyroid hormone levels and BMD were within the normal range. All cases of fibrosis were detected in children with NASH. On multivariable linear regression with correction for age, gender, and BMI, 25-OH-VD levels were found to be 9(95%CI 12-6) ng/ml lower inchildren with NASH than in those without NASH (P

Original languageEnglish
Pages (from-to)547-553
Number of pages7
JournalEuropean Journal of Endocrinology
Issue number4
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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