The comparison of 20 untreated spasmophilic patients (2 men, 18 women) with 25 healthy subjects revealed no significant differences in vitamin D metabolite plasma levels or in other laboratory indexes of calcium metabolism except for ionized and cytosolic free calcium levels which were lower in the former group (P <0.01; P <0.001). After 3 months treatment with calcitonin and 25-hydroxyvitamin D there was a clear improvement in patient symptoms, no significant modification of 1,25-dihydroxy vitamin D levels and significant increases in 25-hydroxyvitamin D, cytosolic free calcium and urinary calcium (P <0.001, P <0.001 and P <0.01, respectively). We conclude that high plasma levels of 25-hydroxy-vitamin D play an important role in restoring normal cytosolic free calcium levels and reducing clinical manifestations in spasmophilia. spasmophilia / vitamin D / 25-hydroxyvitamin D.
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