Vitamin D metabolites in spasmophilia

MP Caraceni, GG Gandolini, F. Campanini, MA lannetta, S. Ortolani

Research output: Contribution to journalArticle

Abstract

The comparison of 20 untreated spasmophilic patients (2 men, 18 women) with 25 healthy subjects revealed no significant differences in vitamin D metabolite plasma levels or in other laboratory indexes of calcium metabolism except for ionized and cytosolic free calcium levels which were lower in the former group (P <0.01; P <0.001). After 3 months treatment with calcitonin and 25-hydroxyvitamin D there was a clear improvement in patient symptoms, no significant modification of 1,25-dihydroxy vitamin D levels and significant increases in 25-hydroxyvitamin D, cytosolic free calcium and urinary calcium (P <0.001, P <0.001 and P <0.01, respectively). We conclude that high plasma levels of 25-hydroxy-vitamin D play an important role in restoring normal cytosolic free calcium levels and reducing clinical manifestations in spasmophilia. spasmophilia / vitamin D / 25-hydroxyvitamin D.

Original languageEnglish
Pages (from-to)479-482
Number of pages4
JournalBiomedicine and Pharmacotherapy
Volume44
Issue number9
DOIs
Publication statusPublished - 1990

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Tetany
Vitamin D
Calcium
Calcitonin
Healthy Volunteers
25-hydroxyvitamin D

ASJC Scopus subject areas

  • Pharmacology

Cite this

Caraceni, MP., Gandolini, GG., Campanini, F., lannetta, MA., & Ortolani, S. (1990). Vitamin D metabolites in spasmophilia. Biomedicine and Pharmacotherapy, 44(9), 479-482. https://doi.org/10.1016/0753-3322(90)90209-R

Vitamin D metabolites in spasmophilia. / Caraceni, MP; Gandolini, GG; Campanini, F.; lannetta, MA; Ortolani, S.

In: Biomedicine and Pharmacotherapy, Vol. 44, No. 9, 1990, p. 479-482.

Research output: Contribution to journalArticle

Caraceni, MP, Gandolini, GG, Campanini, F, lannetta, MA & Ortolani, S 1990, 'Vitamin D metabolites in spasmophilia', Biomedicine and Pharmacotherapy, vol. 44, no. 9, pp. 479-482. https://doi.org/10.1016/0753-3322(90)90209-R
Caraceni, MP ; Gandolini, GG ; Campanini, F. ; lannetta, MA ; Ortolani, S. / Vitamin D metabolites in spasmophilia. In: Biomedicine and Pharmacotherapy. 1990 ; Vol. 44, No. 9. pp. 479-482.
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