Vitamin D: not just the bone: Evidence for beneficial pleiotropic extraskeletal effects

Massimiliano Caprio, Marco Infante, Matilde Calanchini, Caterina Mammi, Andrea Fabbri

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.

Original languageEnglish
Pages (from-to)27-41
JournalEating and Weight Disorders
Volume22
Issue number1
DOIs
Publication statusPublished - Mar 2017

Fingerprint

Vitamin D
Bone and Bones
Autoimmune Diseases
Adipose Tissue
Muscles
Endocrine System
Parathyroid Glands
Endocrine Cells
Metabolic Diseases
Human Genome
Cardiovascular System
Cell Cycle Checkpoints
Parathyroid Hormone
Vitamins
Phosphorus
Intestines
Cell Differentiation
Immune System
Homeostasis
Fats

Keywords

  • Adipose tissue
  • Anorexia nervosa
  • Autoimmune diseases
  • Diabetes
  • Eating disorders
  • Glucose metabolism
  • Hashimoto thyroiditis
  • Multiple sclerosis
  • Obesity
  • Skeletal muscle

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Vitamin D: not just the bone : Evidence for beneficial pleiotropic extraskeletal effects. / Caprio, Massimiliano; Infante, Marco; Calanchini, Matilde; Mammi, Caterina; Fabbri, Andrea.

In: Eating and Weight Disorders, Vol. 22, No. 1, 03.2017, p. 27-41.

Research output: Contribution to journalReview article

@article{59b866ff10084f48bc9536c814c82d60,
title = "Vitamin D: not just the bone: Evidence for beneficial pleiotropic extraskeletal effects",
abstract = "Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 {\%} of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.",
keywords = "Adipose tissue, Anorexia nervosa, Autoimmune diseases, Diabetes, Eating disorders, Glucose metabolism, Hashimoto thyroiditis, Multiple sclerosis, Obesity, Skeletal muscle",
author = "Massimiliano Caprio and Marco Infante and Matilde Calanchini and Caterina Mammi and Andrea Fabbri",
year = "2017",
month = "3",
doi = "10.1007/s40519-016-0312-6",
language = "English",
volume = "22",
pages = "27--41",
journal = "Eating and Weight Disorders",
issn = "1124-4909",
publisher = "Editrice Kurtis s.r.l.",
number = "1",

}

TY - JOUR

T1 - Vitamin D: not just the bone

T2 - Evidence for beneficial pleiotropic extraskeletal effects

AU - Caprio, Massimiliano

AU - Infante, Marco

AU - Calanchini, Matilde

AU - Mammi, Caterina

AU - Fabbri, Andrea

PY - 2017/3

Y1 - 2017/3

N2 - Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.

AB - Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.

KW - Adipose tissue

KW - Anorexia nervosa

KW - Autoimmune diseases

KW - Diabetes

KW - Eating disorders

KW - Glucose metabolism

KW - Hashimoto thyroiditis

KW - Multiple sclerosis

KW - Obesity

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=85014466158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014466158&partnerID=8YFLogxK

U2 - 10.1007/s40519-016-0312-6

DO - 10.1007/s40519-016-0312-6

M3 - Review article

VL - 22

SP - 27

EP - 41

JO - Eating and Weight Disorders

JF - Eating and Weight Disorders

SN - 1124-4909

IS - 1

ER -