Abstract
Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.
| Original language | English |
|---|---|
| Pages (from-to) | 27-41 |
| Journal | Eating and Weight Disorders |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 2017 |
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Keywords
- Adipose tissue
- Anorexia nervosa
- Autoimmune diseases
- Diabetes
- Eating disorders
- Glucose metabolism
- Hashimoto thyroiditis
- Multiple sclerosis
- Obesity
- Skeletal muscle
ASJC Scopus subject areas
- Clinical Psychology
- Psychiatry and Mental health
Cite this
Vitamin D: not just the bone : Evidence for beneficial pleiotropic extraskeletal effects. / Caprio, Massimiliano; Infante, Marco; Calanchini, Matilde; Mammi, Caterina; Fabbri, Andrea.
In: Eating and Weight Disorders, Vol. 22, No. 1, 03.2017, p. 27-41.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Vitamin D: not just the bone
T2 - Evidence for beneficial pleiotropic extraskeletal effects
AU - Caprio, Massimiliano
AU - Infante, Marco
AU - Calanchini, Matilde
AU - Mammi, Caterina
AU - Fabbri, Andrea
PY - 2017/3
Y1 - 2017/3
N2 - Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.
AB - Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects.
KW - Adipose tissue
KW - Anorexia nervosa
KW - Autoimmune diseases
KW - Diabetes
KW - Eating disorders
KW - Glucose metabolism
KW - Hashimoto thyroiditis
KW - Multiple sclerosis
KW - Obesity
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85014466158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014466158&partnerID=8YFLogxK
U2 - 10.1007/s40519-016-0312-6
DO - 10.1007/s40519-016-0312-6
M3 - Review article
VL - 22
SP - 27
EP - 41
JO - Eating and Weight Disorders
JF - Eating and Weight Disorders
SN - 1124-4909
IS - 1
ER -