TY - JOUR
T1 - Vitamin D receptor agonists in the treatment of autoimmune diseases
T2 - Selective targeting of myeloid but not plasmacytoid dendritic cells
AU - Penna, Giuseppe
AU - Amuchastegui, Susana
AU - Laverny, Gilles
AU - Adorini, Luciano
PY - 2007/12
Y1 - 2007/12
N2 - Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium and bone metabolism and to regulate growth and differentiation of many cell types. More recently, it has become clear that VDR agonists possess immunoregulatory properties and, in particular, pronounced protolerogenic activities. These agents have been shown to be effective in several models of autoimmune diseases and are the most used topical agents in the treatment of psoriasis, a Th1 and Th17 cell-mediated autoimmune disease of the skin, indicating their potential applicability in the treatment of a variety of autoimmune diseases. VDR agonists can act directly on T cells, but dendritic cells (DCs) seem to be their primary targets. A potentially very important activity of VDR agonists is their capacity to induce in vitro and in vivo tolerogenic DCs able to enhance CD4+CD25+ suppressor T cells that, in turn, inhibit effector T-cell responses. Novel data now show that VDR agonists selectively modulate tolerogenic properties in blood myeloid but not plasmacytoid DCs, shedding new light on the multifaceted immunoregulatory properties of these agents.
AB - Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium and bone metabolism and to regulate growth and differentiation of many cell types. More recently, it has become clear that VDR agonists possess immunoregulatory properties and, in particular, pronounced protolerogenic activities. These agents have been shown to be effective in several models of autoimmune diseases and are the most used topical agents in the treatment of psoriasis, a Th1 and Th17 cell-mediated autoimmune disease of the skin, indicating their potential applicability in the treatment of a variety of autoimmune diseases. VDR agonists can act directly on T cells, but dendritic cells (DCs) seem to be their primary targets. A potentially very important activity of VDR agonists is their capacity to induce in vitro and in vivo tolerogenic DCs able to enhance CD4+CD25+ suppressor T cells that, in turn, inhibit effector T-cell responses. Novel data now show that VDR agonists selectively modulate tolerogenic properties in blood myeloid but not plasmacytoid DCs, shedding new light on the multifaceted immunoregulatory properties of these agents.
KW - 1,25-Dihydroxyvitamin D
KW - Autoimmune diseases
KW - Myeloid dendritic cells
KW - Plasmacytoid dendritic cells
KW - Tolerogenic dendritic cells
UR - http://www.scopus.com/inward/record.url?scp=39749149619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39749149619&partnerID=8YFLogxK
U2 - 10.1359/jbmr.07s217
DO - 10.1359/jbmr.07s217
M3 - Article
C2 - 18290726
AN - SCOPUS:39749149619
VL - 22
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - SUPPL. 2
ER -