Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations

Mazda Jenab; James McKay; Hendrik B. Bueno-De-Mesquita; Franzel J B Van Duijnhoven; Pietro Ferrari; Nadia Slimani; Eugène H J M Jansen; Tobias Pischon; Sabina Rinaldi; Anne Tjønneland; Anja Olsen; Kim Overvad; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Pierre Engel; Rudolf Kaaks; Jakob Linseisen; Heiner Boeing; Eva Fisher; Antonia Trichopoulou; Vardis Dilis; Erifili Oustoglou; Franco Berrino; Paolo Vineis; Amalia Mattiello; Giovanna Masala; Rosario Tumino; Alina Vrieling; Carla H. Van Gils; Petra H. Peeters; Magritt Brustad; Eiliv Lund; María Dolores Chirlaque; Aurelio Barricarte; Laudina Rodríguez Suárez; Esther Molina; Miren Dorronsoro; Núria Sala; Göran Hallmans; Richard Palmqvist; Andrew Roddam; Timothy J. Key; Kay Tee Khaw; Sheila Bingham; Paolo Boffetta; Philippe Autier; Graham Byrnes; Teresa Norat; Elio Riboli

doi:10.1158/1055-9965.EPI-09-0319

Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations

Mazda Jenab, James McKay, Hendrik B. Bueno-De-Mesquita, Franzel J B Van Duijnhoven, Pietro Ferrari, Nadia Slimani, Eugène H J M Jansen, Tobias Pischon, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Pierre Engel, Rudolf Kaaks, Jakob Linseisen, Heiner Boeing, Eva Fisher, Antonia TrichopoulouVardis Dilis, Erifili Oustoglou, Franco Berrino, Paolo Vineis, Amalia Mattiello, Giovanna Masala, Rosario Tumino, Alina Vrieling, Carla H. Van Gils, Petra H. Peeters, Magritt Brustad, Eiliv Lund, María Dolores Chirlaque, Aurelio Barricarte, Laudina Rodríguez Suárez, Esther Molina, Miren Dorronsoro, Núria Sala, Göran Hallmans, Richard Palmqvist, Andrew Roddam, Timothy J. Key, Kay Tee Khaw, Sheila Bingham, Paolo Boffetta, Philippe Autier, Graham Byrnes, Teresa Norat, Elio Riboli

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article

Abstract

Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake.

Original language	English
Pages (from-to)	2485-2491
Number of pages	7
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	18
Issue number	9
DOIs	https://doi.org/10.1158/1055-9965.EPI-09-0319
Publication status	Published - Sep 2009

ASJC Scopus subject areas

Epidemiology
Oncology

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Jenab, M., McKay, J., Bueno-De-Mesquita, H. B., Van Duijnhoven, F. J. B., Ferrari, P., Slimani, N., Jansen, E. H. J. M., Pischon, T., Rinaldi, S., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M. C., Clavel-Chapelon, F., Engel, P., Kaaks, R., Linseisen, J., Boeing, H., Fisher, E., ... Riboli, E. (2009). Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. Cancer Epidemiology Biomarkers and Prevention, 18(9), 2485-2491. https://doi.org/10.1158/1055-9965.EPI-09-0319

Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. / Jenab, Mazda; McKay, James; Bueno-De-Mesquita, Hendrik B.; Van Duijnhoven, Franzel J B; Ferrari, Pietro; Slimani, Nadia; Jansen, Eugène H J M; Pischon, Tobias; Rinaldi, Sabina; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Engel, Pierre; Kaaks, Rudolf; Linseisen, Jakob; Boeing, Heiner; Fisher, Eva; Trichopoulou, Antonia; Dilis, Vardis; Oustoglou, Erifili; Berrino, Franco; Vineis, Paolo; Mattiello, Amalia; Masala, Giovanna; Tumino, Rosario; Vrieling, Alina; Van Gils, Carla H.; Peeters, Petra H.; Brustad, Magritt; Lund, Eiliv; Chirlaque, María Dolores; Barricarte, Aurelio; Suárez, Laudina Rodríguez; Molina, Esther; Dorronsoro, Miren; Sala, Núria; Hallmans, Göran; Palmqvist, Richard; Roddam, Andrew; Key, Timothy J.; Khaw, Kay Tee; Bingham, Sheila; Boffetta, Paolo; Autier, Philippe; Byrnes, Graham; Norat, Teresa; Riboli, Elio.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 18, No. 9, 09.2009, p. 2485-2491.

Research output: Contribution to journal › Article

Jenab, M, McKay, J, Bueno-De-Mesquita, HB, Van Duijnhoven, FJB, Ferrari, P, Slimani, N, Jansen, EHJM, Pischon, T, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Engel, P, Kaaks, R, Linseisen, J, Boeing, H, Fisher, E, Trichopoulou, A, Dilis, V, Oustoglou, E, Berrino, F, Vineis, P, Mattiello, A, Masala, G, Tumino, R, Vrieling, A, Van Gils, CH, Peeters, PH, Brustad, M, Lund, E, Chirlaque, MD, Barricarte, A, Suárez, LR, Molina, E, Dorronsoro, M, Sala, N, Hallmans, G, Palmqvist, R, Roddam, A, Key, TJ, Khaw, KT, Bingham, S, Boffetta, P, Autier, P, Byrnes, G, Norat, T & Riboli, E 2009, 'Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations', Cancer Epidemiology Biomarkers and Prevention, vol. 18, no. 9, pp. 2485-2491. https://doi.org/10.1158/1055-9965.EPI-09-0319

Jenab, Mazda ; McKay, James ; Bueno-De-Mesquita, Hendrik B. ; Van Duijnhoven, Franzel J B ; Ferrari, Pietro ; Slimani, Nadia ; Jansen, Eugène H J M ; Pischon, Tobias ; Rinaldi, Sabina ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Françoise ; Engel, Pierre ; Kaaks, Rudolf ; Linseisen, Jakob ; Boeing, Heiner ; Fisher, Eva ; Trichopoulou, Antonia ; Dilis, Vardis ; Oustoglou, Erifili ; Berrino, Franco ; Vineis, Paolo ; Mattiello, Amalia ; Masala, Giovanna ; Tumino, Rosario ; Vrieling, Alina ; Van Gils, Carla H. ; Peeters, Petra H. ; Brustad, Magritt ; Lund, Eiliv ; Chirlaque, María Dolores ; Barricarte, Aurelio ; Suárez, Laudina Rodríguez ; Molina, Esther ; Dorronsoro, Miren ; Sala, Núria ; Hallmans, Göran ; Palmqvist, Richard ; Roddam, Andrew ; Key, Timothy J. ; Khaw, Kay Tee ; Bingham, Sheila ; Boffetta, Paolo ; Autier, Philippe ; Byrnes, Graham ; Norat, Teresa ; Riboli, Elio. / Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. In: Cancer Epidemiology Biomarkers and Prevention. 2009 ; Vol. 18, No. 9. pp. 2485-2491.

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title = "Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations",

abstract = "Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake.",

author = "Mazda Jenab and James McKay and Bueno-De-Mesquita, {Hendrik B.} and {Van Duijnhoven}, {Franzel J B} and Pietro Ferrari and Nadia Slimani and Jansen, {Eug{\`e}ne H J M} and Tobias Pischon and Sabina Rinaldi and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Boutron-Ruault, {Marie Christine} and Fran{\c c}oise Clavel-Chapelon and Pierre Engel and Rudolf Kaaks and Jakob Linseisen and Heiner Boeing and Eva Fisher and Antonia Trichopoulou and Vardis Dilis and Erifili Oustoglou and Franco Berrino and Paolo Vineis and Amalia Mattiello and Giovanna Masala and Rosario Tumino and Alina Vrieling and {Van Gils}, {Carla H.} and Peeters, {Petra H.} and Magritt Brustad and Eiliv Lund and Chirlaque, {Mar{\'i}a Dolores} and Aurelio Barricarte and Su{\'a}rez, {Laudina Rodr{\'i}guez} and Esther Molina and Miren Dorronsoro and N{\'u}ria Sala and G{\"o}ran Hallmans and Richard Palmqvist and Andrew Roddam and Key, {Timothy J.} and Khaw, {Kay Tee} and Sheila Bingham and Paolo Boffetta and Philippe Autier and Graham Byrnes and Teresa Norat and Elio Riboli",

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AU - Jenab, Mazda

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AU - Van Duijnhoven, Franzel J B

AU - Ferrari, Pietro

AU - Slimani, Nadia

AU - Jansen, Eugène H J M

AU - Pischon, Tobias

AU - Rinaldi, Sabina

AU - Tjønneland, Anne

AU - Olsen, Anja

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AU - Boutron-Ruault, Marie Christine

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AU - Engel, Pierre

AU - Kaaks, Rudolf

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AU - Fisher, Eva

AU - Trichopoulou, Antonia

AU - Dilis, Vardis

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AU - Berrino, Franco

AU - Vineis, Paolo

AU - Mattiello, Amalia

AU - Masala, Giovanna

AU - Tumino, Rosario

AU - Vrieling, Alina

AU - Van Gils, Carla H.

AU - Peeters, Petra H.

AU - Brustad, Magritt

AU - Lund, Eiliv

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AU - Barricarte, Aurelio

AU - Suárez, Laudina Rodríguez

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AU - Hallmans, Göran

AU - Palmqvist, Richard

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AU - Key, Timothy J.

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AU - Bingham, Sheila

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AU - Norat, Teresa

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PY - 2009/9

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