Abstract
Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake.
| Original language | English |
|---|---|
| Pages (from-to) | 2485-2491 |
| Number of pages | 7 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 18 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2009 |
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ASJC Scopus subject areas
- Epidemiology
- Oncology
Cite this
Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. / Jenab, Mazda; McKay, James; Bueno-De-Mesquita, Hendrik B.; Van Duijnhoven, Franzel J B; Ferrari, Pietro; Slimani, Nadia; Jansen, Eugène H J M; Pischon, Tobias; Rinaldi, Sabina; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Engel, Pierre; Kaaks, Rudolf; Linseisen, Jakob; Boeing, Heiner; Fisher, Eva; Trichopoulou, Antonia; Dilis, Vardis; Oustoglou, Erifili; Berrino, Franco; Vineis, Paolo; Mattiello, Amalia; Masala, Giovanna; Tumino, Rosario; Vrieling, Alina; Van Gils, Carla H.; Peeters, Petra H.; Brustad, Magritt; Lund, Eiliv; Chirlaque, María Dolores; Barricarte, Aurelio; Suárez, Laudina Rodríguez; Molina, Esther; Dorronsoro, Miren; Sala, Núria; Hallmans, Göran; Palmqvist, Richard; Roddam, Andrew; Key, Timothy J.; Khaw, Kay Tee; Bingham, Sheila; Boffetta, Paolo; Autier, Philippe; Byrnes, Graham; Norat, Teresa; Riboli, Elio.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 18, No. 9, 09.2009, p. 2485-2491.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations
AU - Jenab, Mazda
AU - McKay, James
AU - Bueno-De-Mesquita, Hendrik B.
AU - Van Duijnhoven, Franzel J B
AU - Ferrari, Pietro
AU - Slimani, Nadia
AU - Jansen, Eugène H J M
AU - Pischon, Tobias
AU - Rinaldi, Sabina
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Françoise
AU - Engel, Pierre
AU - Kaaks, Rudolf
AU - Linseisen, Jakob
AU - Boeing, Heiner
AU - Fisher, Eva
AU - Trichopoulou, Antonia
AU - Dilis, Vardis
AU - Oustoglou, Erifili
AU - Berrino, Franco
AU - Vineis, Paolo
AU - Mattiello, Amalia
AU - Masala, Giovanna
AU - Tumino, Rosario
AU - Vrieling, Alina
AU - Van Gils, Carla H.
AU - Peeters, Petra H.
AU - Brustad, Magritt
AU - Lund, Eiliv
AU - Chirlaque, María Dolores
AU - Barricarte, Aurelio
AU - Suárez, Laudina Rodríguez
AU - Molina, Esther
AU - Dorronsoro, Miren
AU - Sala, Núria
AU - Hallmans, Göran
AU - Palmqvist, Richard
AU - Roddam, Andrew
AU - Key, Timothy J.
AU - Khaw, Kay Tee
AU - Bingham, Sheila
AU - Boffetta, Paolo
AU - Autier, Philippe
AU - Byrnes, Graham
AU - Norat, Teresa
AU - Riboli, Elio
PY - 2009/9
Y1 - 2009/9
N2 - Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake.
AB - Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake.
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UR - http://www.scopus.com/inward/citedby.url?scp=70349342810&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-09-0319
DO - 10.1158/1055-9965.EPI-09-0319
M3 - Article
C2 - 19706842
AN - SCOPUS:70349342810
VL - 18
SP - 2485
EP - 2491
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 9
ER -