Vitamin D receptor (VDR) gene polymorphisms and age onset in type 1 diabetes mellitus

Jaqueline De Azevêdo Silva, Rafael Lima Guimarães, Lucas André Cavalcanti Brandão, Jacqueline Araujo, Ludovica Segat, Sergio Crovella, Paula Sandrin-Garcia

Research output: Contribution to journalArticle

Abstract

Vitamin D receptor is a mediator of immune responses through the action of vitamin D, which is capable of regulate the insulin secretion by the pancreas. Since polymorphisms in the vitamin D receptor (VDR) gene might modulate vitamin D function, and thus immunologic response, VDR is possibly able to influence the predisposition to type 1 diabetes mellitus (T1DM). The aim of this work was to perform an association study among VDR polymorphisms and T1DM susceptibility, as well as the correlation with the disease onset. Two hundred and four T1DM patients and 217 controls, from Northeast Brazil, were genotyped for five tagSNPs, covering the whole VDR gene. Our results indicated an association between rs1540339 and rs4760648 SNPs (pp;=p;0.02 and pp;=p;0.03, respectively) and T1DM. No association was found with T1DM onset and age at diagnose. To our knowledge, this is the first association study in T1DM where the whole VDR gene was analyzed, and our results indicate that VDR polymorphisms could be important for T1DM susceptibility, but do not seem to be associated to age at disease onset.

Original languageEnglish
Pages (from-to)382-387
Number of pages6
JournalAutoimmunity
Volume46
Issue number6
DOIs
Publication statusPublished - Sep 2013

Keywords

  • SNPs
  • T1DM
  • VDR

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    De Azevêdo Silva, J., Guimarães, R. L., Brandão, L. A. C., Araujo, J., Segat, L., Crovella, S., & Sandrin-Garcia, P. (2013). Vitamin D receptor (VDR) gene polymorphisms and age onset in type 1 diabetes mellitus. Autoimmunity, 46(6), 382-387. https://doi.org/10.3109/08916934.2013.795952