TY - JOUR
T1 - Vitamin D, reproductive disorders and assisted reproduction
T2 - evidences and perspectives
AU - Fichera, Michele
AU - Török, Péter
AU - Tesarik, Jan
AU - Della Corte, Luigi
AU - Rizzo, Gianluca
AU - Garzon, Simone
AU - Carlea, Annunziata
AU - Di Angelo Antonio, Silvia
AU - Zito, Gabriella
AU - Panella, Marco Marzio
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Vitamin D is an important nutrient involved in many fundamental health outcomes. However, its influence on female reproductive function remains ambiguous. Cholecalciferol seems to have a role in the reproductive processes and in the patients affected by polycystic ovary syndrome, endometriosis, uterine myomas and premature ovarian failure. Moreover, it may play an important role in the assisted reproductive techniques, given that it is capable of influencing oocyte quality, but also an adequate preparation of the endometrium for embryonic implantation. Although promising, available evidence is based on a limited number of in vitro, in vivo and clinical studies. We provide an overview of the association between vitamin D and female infertility reporting the most recent data published in the literature. Nevertheless, properly randomised clinical trials are mandatory to achieve more conclusive results about the promising role of vitamin D in the management of female assisted reproduction.
AB - Vitamin D is an important nutrient involved in many fundamental health outcomes. However, its influence on female reproductive function remains ambiguous. Cholecalciferol seems to have a role in the reproductive processes and in the patients affected by polycystic ovary syndrome, endometriosis, uterine myomas and premature ovarian failure. Moreover, it may play an important role in the assisted reproductive techniques, given that it is capable of influencing oocyte quality, but also an adequate preparation of the endometrium for embryonic implantation. Although promising, available evidence is based on a limited number of in vitro, in vivo and clinical studies. We provide an overview of the association between vitamin D and female infertility reporting the most recent data published in the literature. Nevertheless, properly randomised clinical trials are mandatory to achieve more conclusive results about the promising role of vitamin D in the management of female assisted reproduction.
KW - assisted reproduction
KW - endometriosis
KW - fibroids
KW - infertility
KW - PCOS
KW - vitamin D
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U2 - 10.1080/09637486.2019.1661978
DO - 10.1080/09637486.2019.1661978
M3 - Article
AN - SCOPUS:85071984672
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
SN - 0963-7486
ER -