Vitamin D status in inpatients admitted to an internal medicine department

Silvana Muscarella, Paola Filabozzi, Grazia D'Amico, Maria Lucia Mascia, Maria Antonietta Annese, Alfredo Scillitani, Vincenzo Carnevale

Research output: Contribution to journalArticlepeer-review


Background/Aims: A role of hypovitaminosis D has been advocated in several medical conditions. We investigated vitamin D status in medical inpatients, compared to a blood donors' group from the same area. Methods: Fifty-nine consecutive medical patients were recruited at hospital admission, concomitantly to 207 blood donors of both genders. Serum calcium, albumin, phosphate, creatinine, alkaline phosphatase total activity, 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) were assessed from April to May 2005. Results: In patients, 25(OH)D values were lower (13.1 ± 9.2 vs. 16.3 ± 8.5 ng/ml; p <0.02) and PTH values higher (73.9 ± 77.7 vs. 53.4 ± 24.3 pg/ml; p <0.01) than in controls, whose mean age was lower (62.5 ± 14.5 vs. 45.8 ± 15.6 years, p <0.01). Such differences were not confirmed when comparing patients to a subgroup of age and sex-matched controls drawn from the whole sample of blood donors. In both patients and controls there was a trend towards a negative correlation between 25(OH)D and age and a positive correlation between PTH and age. The prevalence of 25(OH)D 2 = 9.95; p <0.002), but not in respect to the subgroup of matched controls (58 vs. 44%; χ2 = 2.09; p = 0.14). The prevalence of severe vitamin D deficiency, 25(OH)D 2 = 6.75; p <0.01). Conclusion: Hypovitaminosis D, defined as 25(OH)D

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalHormone Research
Issue number5
Publication statusPublished - Oct 2006


  • Chronic disorders
  • Hospitalization
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology


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