Vitamin D status in primary hyperparathyroidism: effect of genetic background

Claudia Battista, Vito Guarnieri, Vincenzo Carnevale, Filomena Baorda, M. Pileri, Maria Garrubba, Antonio Stefano Salcuni, Iacopo Chiodini, S. Minisola, Elisabetta Romagnoli, Cristina Eller-Vainicher, Stefano Angelo Santini, Salvatore Parisi, Vincenzo Frusciante, Andrea Fontana, Massimiliano Copetti, Geoffrey N. Hendy, Alfredo Scillitani, David E C Cole

Research output: Contribution to journalArticle

Abstract

Primary hyperparathyroidism (PHPT) is associated with hypovitaminosis D as assessed by serum total 25-hydroxyvitamin D (TotalD) levels. The aim of this study is to evaluate whether this is also the case for the calculated bioavailable 25-hydroxyvitamin D (BioD) or free 25-hydroxyvitamin D (FreeD), and whether the vitamin D status is influenced by genetic background. We compared vitamin D status of 88 PHPT patients each with a matched healthy family member sharing genetic background, i.e., first-degree relative (FDR), or not, namely an in-law relative (ILR). We compared TotalD and vitamin D-binding protein (DBP), using the latter to calculate BioD and FreeD. We also genotyped two common DBP polymorphisms (rs7041 and rs4588) likely to affect the affinity for and levels of vitamin D metabolites. TotalD was lower (p <0.001) in PHPT (12.3 ± 6.6 ng/mL) than either family member group (FDR: 19.4 ± 12.1 and ILR: 23.2 ± 14.1), whether adjusted for DBP or not. DBP levels were also significantly lower (p <0.001) in PHPT (323 ± 73 mg/L) versus FDR (377 ± 98) or ILR (382 ± 101). The differences between PHPT and control groups for TotalD, BioD, and FreeD were maintained after adjustment for season, gender, and serum creatinine. 25-hydroxyvitamin D, evaluated as total, free, or bioavailable fractions, is decreased in PHPT. No difference was seen between first-degree relative and in-law controls, suggesting that neither genetic nor non-genetic background greatly influences the genesis of the hypovitaminosis D seen in PHPT.

Original languageEnglish
Pages (from-to)266-272
JournalEndocrine
Volume55
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Primary Hyperparathyroidism
Vitamin D
Carrier Proteins
25-hydroxyvitamin D
Genetic Background
Vitamin D-Binding Protein
Serum
Creatinine

Keywords

  • Bioavailable 25-hydroxyvitamin D
  • Free 25-hydroxyvitamin D
  • Primary hyperparathyroidism
  • Vitamin D-binding protein

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Vitamin D status in primary hyperparathyroidism : effect of genetic background. / Battista, Claudia; Guarnieri, Vito; Carnevale, Vincenzo; Baorda, Filomena; Pileri, M.; Garrubba, Maria; Salcuni, Antonio Stefano; Chiodini, Iacopo; Minisola, S.; Romagnoli, Elisabetta; Eller-Vainicher, Cristina; Santini, Stefano Angelo; Parisi, Salvatore; Frusciante, Vincenzo; Fontana, Andrea; Copetti, Massimiliano; Hendy, Geoffrey N.; Scillitani, Alfredo; Cole, David E C.

In: Endocrine, Vol. 55, No. 1, 2017, p. 266-272.

Research output: Contribution to journalArticle

Battista, C, Guarnieri, V, Carnevale, V, Baorda, F, Pileri, M, Garrubba, M, Salcuni, AS, Chiodini, I, Minisola, S, Romagnoli, E, Eller-Vainicher, C, Santini, SA, Parisi, S, Frusciante, V, Fontana, A, Copetti, M, Hendy, GN, Scillitani, A & Cole, DEC 2017, 'Vitamin D status in primary hyperparathyroidism: effect of genetic background', Endocrine, vol. 55, no. 1, pp. 266-272. https://doi.org/10.1007/s12020-016-0974-x
Battista, Claudia ; Guarnieri, Vito ; Carnevale, Vincenzo ; Baorda, Filomena ; Pileri, M. ; Garrubba, Maria ; Salcuni, Antonio Stefano ; Chiodini, Iacopo ; Minisola, S. ; Romagnoli, Elisabetta ; Eller-Vainicher, Cristina ; Santini, Stefano Angelo ; Parisi, Salvatore ; Frusciante, Vincenzo ; Fontana, Andrea ; Copetti, Massimiliano ; Hendy, Geoffrey N. ; Scillitani, Alfredo ; Cole, David E C. / Vitamin D status in primary hyperparathyroidism : effect of genetic background. In: Endocrine. 2017 ; Vol. 55, No. 1. pp. 266-272.
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